264228

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pemIK/MazF-doc
Location 8119..8702 Replicon plasmid unnamedA
Accession NZ_CP110785
Organism Staphylococcus capitis strain CCSM0123

Toxin (Protein)


Gene name pemK Uniprot ID -
Locus tag OP858_RS12215 Protein ID WP_111412670.1
Coordinates 8119..8457 (-) Length 113 a.a.

Antitoxin (Protein)


Gene name pemI Uniprot ID -
Locus tag OP858_RS12220 Protein ID WP_070664439.1
Coordinates 8454..8702 (-) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OP858_RS12190 (OP858_12190) 5074..5511 + 438 WP_070664071.1 hypothetical protein -
OP858_RS12195 (OP858_12195) 5650..6072 - 423 WP_267263620.1 IS200/IS605 family transposase -
OP858_RS12200 (OP858_12200) 6171..7313 + 1143 WP_267263621.1 RNA-guided endonuclease TnpB family protein -
OP858_RS12205 (OP858_12205) 7438..7608 + 171 WP_165353544.1 hypothetical protein -
OP858_RS12210 (OP858_12210) 7685..8062 + 378 WP_267263622.1 hypothetical protein -
OP858_RS12215 (OP858_12215) 8119..8457 - 339 WP_111412670.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
OP858_RS12220 (OP858_12220) 8454..8702 - 249 WP_070664439.1 AbrB family transcriptional regulator Antitoxin
OP858_RS12225 (OP858_12225) 8864..9697 - 834 WP_267263623.1 trypsin-like peptidase domain-containing protein -
OP858_RS12230 (OP858_12230) 9716..10933 - 1218 WP_267263624.1 DUF5011 domain-containing protein -
OP858_RS12235 (OP858_12235) 10959..11366 - 408 Protein_14 CHAP domain-containing protein -
OP858_RS12240 (OP858_12240) 11579..11875 - 297 WP_070664421.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..48504 48504


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(4-106)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 113 a.a.        Molecular weight: 13090.29 Da        Isoelectric Point: 10.0249

>T264228 WP_111412670.1 NZ_CP110785:c8457-8119 [Staphylococcus capitis]
MSIKQFDIYYIDLDPTRGREKQKIRPCLIVNNKMTIDGTNFVWVLPITNREKRYPLDIELKTKKGLVTGVIDTLQIRALD
LSVREHNYKDKLQDNLKNVVLQAIQTYLKPSS

Download         Length: 339 bp

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 9222.30 Da        Isoelectric Point: 4.5463

>AT264228 WP_070664439.1 NZ_CP110785:c8702-8454 [Staphylococcus capitis]
MIKTSERIFKSGNSRAISLSKQTIQLADFEVGDKVEVSEINGGLFIKKKEESIEDEITNFFKNGGRYTESEIDFGESVGR
EI

Download         Length: 249 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References