Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 831203..831726 Replicon chromosome
Accession NZ_CP110784
Organism Staphylococcus capitis strain CCSM0123

Toxin (Protein)


Gene name mazF Uniprot ID A0A1J4E8Y2
Locus tag OP858_RS04025 Protein ID WP_002435799.1
Coordinates 831370..831726 (+) Length 119 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID A0A1J4E747
Locus tag OP858_RS04020 Protein ID WP_002435513.1
Coordinates 831203..831373 (+) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OP858_RS03995 (OP858_03995) 827030..827509 + 480 WP_002453690.1 PH domain-containing protein -
OP858_RS04000 (OP858_04000) 827502..829001 + 1500 WP_002453689.1 PH domain-containing protein -
OP858_RS04005 (OP858_04005) 828994..829494 + 501 WP_002453688.1 PH domain-containing protein -
OP858_RS04010 (OP858_04010) 829543..829899 + 357 WP_002453687.1 holo-ACP synthase -
OP858_RS04015 (OP858_04015) 829966..831114 + 1149 WP_002453686.1 alanine racemase -
OP858_RS04020 (OP858_04020) 831203..831373 + 171 WP_002435513.1 type II toxin-antitoxin system antitoxin MazE Antitoxin
OP858_RS04025 (OP858_04025) 831370..831726 + 357 WP_002435799.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
OP858_RS04030 (OP858_04030) 832105..833106 + 1002 WP_002453685.1 PP2C family protein-serine/threonine phosphatase -
OP858_RS04035 (OP858_04035) 833208..833534 + 327 WP_002435753.1 anti-sigma factor antagonist -
OP858_RS04040 (OP858_04040) 833536..834015 + 480 WP_002435518.1 anti-sigma B factor RsbW -
OP858_RS04045 (OP858_04045) 833990..834760 + 771 WP_002435824.1 RNA polymerase sigma factor SigB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(1-112)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 119 a.a.        Molecular weight: 13327.44 Da        Isoelectric Point: 9.8770

>T264221 WP_002435799.1 NZ_CP110784:831370-831726 [Staphylococcus capitis]
MIRRGDVYLADLSPVQGSEQGGVRPVVIIQNDTGNKYSPTVIVAAITGRINKAKIPTHVEIEKKKYKLDKDSVILLEQIR
TLDKKRLKEKLTYLSESKMKEVDNALDISLGLHNFDHQ

Download         Length: 357 bp

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6263.87 Da        Isoelectric Point: 4.0121

>AT264221 WP_002435513.1 NZ_CP110784:831203-831373 [Staphylococcus capitis]
MLSFNQSRSHSLEQSLKEGYAQMADLNLSLATEAFPIECEACDCNETYLTSNSKNE

Download         Length: 171 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1J4E8Y2

Antitoxin

Source ID Structure
AlphaFold DB A0A1J4E747

References