Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 820167..820681 Replicon chromosome
Accession NZ_CP110784
Organism Staphylococcus capitis strain CCSM0123

Toxin (Protein)


Gene name TsdT Uniprot ID A0A4U9TAG5
Locus tag OP858_RS03965 Protein ID WP_002453694.1
Coordinates 820475..820681 (+) Length 69 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID A0A1J4E888
Locus tag OP858_RS03960 Protein ID WP_002435858.1
Coordinates 820167..820460 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OP858_RS03935 (OP858_03935) 815327..816115 + 789 WP_267263593.1 hydroxyethylthiazole kinase -
OP858_RS03940 (OP858_03940) 816122..816760 + 639 WP_186334660.1 thiamine phosphate synthase -
OP858_RS03945 (OP858_03945) 816849..817721 + 873 WP_002453697.1 membrane protein insertase YidC -
OP858_RS03950 (OP858_03950) 817780..818442 - 663 WP_002453696.1 HD domain-containing protein -
OP858_RS03955 (OP858_03955) 818497..819981 - 1485 WP_267263552.1 cardiolipin synthase -
OP858_RS03960 (OP858_03960) 820167..820460 + 294 WP_002435858.1 copper-sensing transcriptional repressor CsoR Antitoxin
OP858_RS03965 (OP858_03965) 820475..820681 + 207 WP_002453694.1 hypothetical protein Toxin
OP858_RS03970 (OP858_03970) 820818..820955 + 138 WP_002435861.1 Lmo0850 family protein -
OP858_RS03975 (OP858_03975) 821012..822223 - 1212 WP_002453693.1 FtsW/RodA/SpoVE family cell cycle protein -
OP858_RS03980 (OP858_03980) 822628..823698 + 1071 WP_002435813.1 D-alanine--D-alanine ligase -
OP858_RS03985 (OP858_03985) 823714..825069 + 1356 WP_016898669.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Metal-sensitive transcriptional repressor

(14-92)


Sequences

Toxin        


Download         Length: 69 a.a.        Molecular weight: 7805.85 Da        Isoelectric Point: 4.2087

>T264220 WP_002453694.1 NZ_CP110784:820475-820681 [Staphylococcus capitis]
MENGIVYVANIEAIEEENQLKTRLENMIGVEKVDIDSKVGEIKILFETPANLNSIEKEVYDSGFRVRY

Download         Length: 207 bp

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11065.56 Da        Isoelectric Point: 6.4776

>AT264220 WP_002435858.1 NZ_CP110784:820167-820460 [Staphylococcus capitis]
VTENETAHHSEQTKANLKSRLNRIEGQVRAINRMIEDDVYCDDVLTQIRATRSALNSVATKLLDHHMKSCIMNKVNNGAQ
EEAMEELLVTFQKLIKD

Download         Length: 294 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A4U9TAG5

Antitoxin

Source ID Structure
AlphaFold DB A0A1J4E888

References