Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 4595334..4595954 Replicon chromosome
Accession NZ_CP110775
Organism Citrobacter freundii strain Cf-Emp

Toxin (Protein)


Gene name Hha Uniprot ID R8WYV2
Locus tag OPR78_RS22595 Protein ID WP_002892050.1
Coordinates 4595334..4595552 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID R8WZW8
Locus tag OPR78_RS22600 Protein ID WP_003021733.1
Coordinates 4595580..4595954 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OPR78_RS22560 (4590567) 4590567..4591196 + 630 WP_003835929.1 membrane protein -
OPR78_RS22565 (4591261) 4591261..4591614 + 354 WP_003831033.1 DUF1428 family protein -
OPR78_RS22570 (4591666) 4591666..4593219 - 1554 WP_044699371.1 EAL domain-containing protein -
OPR78_RS22575 (4593408) 4593408..4593668 + 261 WP_003021719.1 type B 50S ribosomal protein L31 -
OPR78_RS22580 (4593670) 4593670..4593810 + 141 WP_005125190.1 type B 50S ribosomal protein L36 -
OPR78_RS22585 (4593889) 4593889..4594359 - 471 WP_003021724.1 YlaC family protein -
OPR78_RS22590 (4594476) 4594476..4595027 - 552 WP_044699372.1 maltose O-acetyltransferase -
OPR78_RS22595 (4595334) 4595334..4595552 - 219 WP_002892050.1 HHA domain-containing protein Toxin
OPR78_RS22600 (4595580) 4595580..4595954 - 375 WP_003021733.1 Hha toxicity modulator TomB Antitoxin
OPR78_RS22605 (4596442) 4596442..4599591 - 3150 WP_003021736.1 efflux RND transporter permease AcrB -
OPR78_RS22610 (4599614) 4599614..4600807 - 1194 WP_003835922.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T264213 WP_002892050.1 NZ_CP110775:c4595552-4595334 [Citrobacter freundii]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14427.23 Da        Isoelectric Point: 5.5653

>AT264213 WP_003021733.1 NZ_CP110775:c4595954-4595580 [Citrobacter freundii]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEQSNHGWVNDPTSATSLQLNELIEHIATFALNYKIKYNEDNKLIAQIDEYL
DDTFMLFSSYGINTQDLQKWRKSGNRLFRCFVNATRANPVSLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2P8K6F2

Antitoxin

Source ID Structure
AlphaFold DB R8WZW8

References