Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tad-ata/COG5606-COG4679
Location 3613294..3613960 Replicon chromosome
Accession NZ_CP110775
Organism Citrobacter freundii strain Cf-Emp

Toxin (Protein)


Gene name tad Uniprot ID A0A0D7LIM5
Locus tag OPR78_RS17905 Protein ID WP_044702260.1
Coordinates 3613294..3613653 (+) Length 120 a.a.

Antitoxin (Protein)


Gene name ata Uniprot ID A0A0D7LIR0
Locus tag OPR78_RS17910 Protein ID WP_003844682.1
Coordinates 3613643..3613960 (+) Length 106 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OPR78_RS17895 (3610694) 3610694..3612325 + 1632 WP_032938230.1 Na/Pi cotransporter family protein -
OPR78_RS17900 (3612391) 3612391..3613080 - 690 WP_003841421.1 dipeptidase PepE -
OPR78_RS17905 (3613294) 3613294..3613653 + 360 WP_044702260.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
OPR78_RS17910 (3613643) 3613643..3613960 + 318 WP_003844682.1 helix-turn-helix transcriptional regulator Antitoxin
OPR78_RS17915 (3613970) 3613970..3614248 - 279 WP_044702262.1 putative addiction module antidote protein -
OPR78_RS17920 (3614652) 3614652..3614813 - 162 WP_003841416.1 phage protein -
OPR78_RS17925 (3614955) 3614955..3615311 + 357 WP_032948294.1 hypothetical protein -
OPR78_RS17930 (3615363) 3615363..3616175 - 813 WP_044702264.1 shikimate 5-dehydrogenase -
OPR78_RS17935 (3616177) 3616177..3617400 - 1224 WP_044702265.1 L-sorbose 1-phosphate reductase -
OPR78_RS17940 (3617469) 3617469..3618293 - 825 WP_003031641.1 PTS system mannose/fructose/sorbose family transporter subunit IID -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(14-106)

Antitoxin

HigA2-like, helix-turn-helix domain

(12-90)


Sequences

Toxin        


Download         Length: 120 a.a.        Molecular weight: 13437.49 Da        Isoelectric Point: 10.2555

>T264210 WP_044702260.1 NZ_CP110775:3613294-3613653 [Citrobacter freundii]
MTKPLYWVGQARKDLIAMPEHVRDTFGFALWLAQQGKQHSQTKPLKGFGGAGVLEVVEDYHGNAWRAVYTIQLKNAVYVL
HVFQKKSVSGKATPKPEIDLIYQRLKAAQRHAQESGYVT

Download         Length: 360 bp

Antitoxin


Download         Length: 106 a.a.        Molecular weight: 11466.35 Da        Isoelectric Point: 9.0005

>AT264210 WP_003844682.1 NZ_CP110775:3613643-3613960 [Citrobacter freundii]
MSHDVETSSGNVYADLGAYDAEQMQLKAQLAMVIGEILQRKGLTQQQAAQLLGMTQPKLSNLLRGQFRGISEAKMLECLV
RLGRDVEIVVGKEGNMSGKLKVKFG

Download         Length: 318 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0D7LIM5

Antitoxin

Source ID Structure
AlphaFold DB A0A0D7LIR0

References