Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/-
Location 2985070..2985701 Replicon chromosome
Accession NZ_CP110775
Organism Citrobacter freundii strain Cf-Emp

Toxin (Protein)


Gene name hicA Uniprot ID A0A0J1MPQ6
Locus tag OPR78_RS14970 Protein ID WP_003837806.1
Coordinates 2985426..2985701 (-) Length 92 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID A0A0J1MMS0
Locus tag OPR78_RS14965 Protein ID WP_003837808.1
Coordinates 2985070..2985429 (-) Length 120 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OPR78_RS14935 (2980168) 2980168..2980833 + 666 WP_044701371.1 7-cyano-7-deazaguanine/7-aminomethyl-7- deazaguanine transporter -
OPR78_RS14940 (2980906) 2980906..2981463 + 558 WP_003837816.1 DcrB family lipoprotein -
OPR78_RS14945 (2981467) 2981467..2982684 - 1218 WP_003846164.1 MFS transporter -
OPR78_RS14950 (2982818) 2982818..2983867 + 1050 WP_003023393.1 AI-2E family transporter -
OPR78_RS14955 (2983930) 2983930..2984508 + 579 WP_003837810.1 4'-phosphopantetheinyl transferase AcpT -
OPR78_RS14960 (2984558) 2984558..2984959 + 402 WP_003023387.1 nickel-responsive transcriptional regulator NikR -
OPR78_RS14965 (2985070) 2985070..2985429 - 360 WP_003837808.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
OPR78_RS14970 (2985426) 2985426..2985701 - 276 WP_003837806.1 type II toxin-antitoxin system HicA family toxin Toxin
OPR78_RS14975 (2985779) 2985779..2986903 - 1125 WP_003837801.1 ABC transporter permease -
OPR78_RS14980 (2986903) 2986903..2989650 - 2748 WP_044701369.1 ribosome-associated ATPase/putative transporter RbbA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(30-80)

Antitoxin

Uncharacterised protein family HicB

(60-112)


Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 10210.88 Da        Isoelectric Point: 10.7228

>T264207 WP_003837806.1 NZ_CP110775:c2985701-2985426 [Citrobacter freundii]
MKEKVLSLRKKQKNTLDQLFKAPTPQGIKWSEIESLIKALGGEIKEGRGSRCKFLLNKSIASFHRPHPSPDTDKGAVENV
RDWLTSIGVKP

Download         Length: 276 bp

Antitoxin


Download         Length: 120 a.a.        Molecular weight: 13198.98 Da        Isoelectric Point: 4.5462

>AT264207 WP_003837808.1 NZ_CP110775:c2985429-2985070 [Citrobacter freundii]
MIKPKTPNSMEIAGQPAVINYVPELNAFRGKFLGLSGYCDFVSDSIQGLQKEGEISLREYLDDCSAAGIEPYANPEKLKT
FTLRYPESFGERLSFAAAEEQVSVNTWIIETLSKSLKQA

Download         Length: 360 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0J1MPQ6

Antitoxin

Source ID Structure
AlphaFold DB A0A0J1MMS0

References