Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 2404943..2405597 Replicon chromosome
Accession NZ_CP110775
Organism Citrobacter freundii strain Cf-Emp

Toxin (Protein)


Gene name cptA Uniprot ID A0A0J1NHY7
Locus tag OPR78_RS12010 Protein ID WP_003026936.1
Coordinates 2404943..2405350 (-) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID A0A6H3AT26
Locus tag OPR78_RS12015 Protein ID WP_003026938.1
Coordinates 2405331..2405597 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OPR78_RS11990 (2400891) 2400891..2402624 - 1734 WP_044700800.1 single-stranded-DNA-specific exonuclease RecJ -
OPR78_RS11995 (2402630) 2402630..2403343 - 714 WP_003026923.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
OPR78_RS12000 (2403367) 2403367..2404263 - 897 WP_003026928.1 site-specific tyrosine recombinase XerD -
OPR78_RS12005 (2404377) 2404377..2404898 + 522 WP_003026933.1 flavodoxin FldB -
OPR78_RS12010 (2404943) 2404943..2405350 - 408 WP_003026936.1 protein YgfX Toxin
OPR78_RS12015 (2405331) 2405331..2405597 - 267 WP_003026938.1 FAD assembly factor SdhE Antitoxin
OPR78_RS12020 (2405854) 2405854..2406834 + 981 WP_003026944.1 tRNA-modifying protein YgfZ -
OPR78_RS12025 (2406928) 2406928..2407587 - 660 WP_003838267.1 hemolysin III family protein -
OPR78_RS12030 (2407750) 2407750..2408061 - 312 WP_044700802.1 N(4)-acetylcytidine aminohydrolase -
OPR78_RS12035 (2408114) 2408114..2408842 + 729 WP_003838265.1 MurR/RpiR family transcriptional regulator -
OPR78_RS12040 (2408963) 2408963..2410396 + 1434 WP_044700805.1 6-phospho-beta-glucosidase BglA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 15953.89 Da        Isoelectric Point: 11.4054

>T264205 WP_003026936.1 NZ_CP110775:c2405350-2404943 [Citrobacter freundii]
VVQWQSDLRVSWRAQWLSLLIHGLVAVFILLMPWPLSYTPLWLVLLSLVVFDSVRSQRRINACQGEIRLLMDGRLRWQGQ
EWSIVSAPWMVKTGMMLRLRSDAGKRQHLWLAADSMDDAEWRDLRRLMLQKAKQK

Download         Length: 408 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10558.09 Da        Isoelectric Point: 5.1700

>AT264205 WP_003026938.1 NZ_CP110775:c2405597-2405331 [Citrobacter freundii]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDEEKRIFIRLLECDDPDLFNWLMNHGKPADAELEQMVRLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0J1NHY7

Antitoxin

Source ID Structure
AlphaFold DB A0A6H3AT26

References