Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-Phd
Location 37595..38272 Replicon chromosome
Accession NZ_CP110774
Organism Acidocella sp. MX-AZ03

Toxin (Protein)


Gene name vapC Uniprot ID K5YSX0
Locus tag GT370_RS00200 Protein ID WP_008495710.1
Coordinates 37595..38026 (-) Length 144 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID K5YTJ1
Locus tag GT370_RS00205 Protein ID WP_008495709.1
Coordinates 38030..38272 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GT370_RS00185 (GT370_00185) 33190..34239 - 1050 WP_039885813.1 IS5 family transposase -
GT370_RS00190 (GT370_00190) 34309..35991 - 1683 WP_270183699.1 tetratricopeptide repeat protein -
GT370_RS00195 (GT370_00195) 36107..37156 + 1050 WP_039885813.1 IS5 family transposase -
GT370_RS00200 (GT370_00200) 37595..38026 - 432 WP_008495710.1 type II toxin-antitoxin system VapC family toxin Toxin
GT370_RS00205 (GT370_00205) 38030..38272 - 243 WP_008495709.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
GT370_RS00210 (GT370_00210) 38368..39030 - 663 WP_008495708.1 hypothetical protein -
GT370_RS00215 (GT370_00215) 39018..39905 - 888 WP_008495707.1 hypothetical protein -
GT370_RS00220 (GT370_00220) 39940..40452 - 513 WP_270183700.1 hypothetical protein -
GT370_RS00225 (GT370_00225) 40739..41428 + 690 WP_008495706.1 hypothetical protein -
GT370_RS00230 (GT370_00230) 41476..42700 + 1225 Protein_39 IS3 family transposase -
GT370_RS00235 (GT370_00235) 42737..42928 - 192 WP_144052869.1 hypothetical protein -
GT370_RS00240 (GT370_00240) 42976..43272 + 297 WP_008495702.1 DUF1778 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-126)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-65)


Sequences

Toxin        


Download         Length: 144 a.a.        Molecular weight: 15468.80 Da        Isoelectric Point: 7.1292

>T264195 WP_008495710.1 NZ_CP110774:c38026-37595 [Acidocella sp. MX-AZ03]
MYLVDTNVISARAPSRVPLPDLAAWMDAHSADLFLSTVTIAEIEDGIAKAKREGATRKARDLTAWLETVLHLYAARILPF
DVASARLAGSLSDCARGQGHAPGFADIIIAATAQHHGLTILTRNLRHFEPLGVAVHDPFIRLP

Download         Length: 432 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8798.05 Da        Isoelectric Point: 5.0348

>AT264195 WP_008495709.1 NZ_CP110774:c38272-38030 [Acidocella sp. MX-AZ03]
MREIQLRDAKASLSAVVDEALRGEPAIITRHGKPEAVILSFEEWQRLSHVPSFGQLLMAAPLDADDLPPRNPSPLRDSGL

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB K5YSX0

Antitoxin

Source ID Structure
AlphaFold DB K5YTJ1

References