Detailed information of TA system TA026419

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/HTH_10(toxin)
• Location: 604680..605659
• Replicon: chromosome
• Accession: NC_017276
• Organism: Sulfolobus islandicus REY15A

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: F0NEE9
• Locus tag: SIRE_RS03205
• Protein ID: WP_014513670.1
• Coordinates: 604680..605294 (-)
• Length: 205 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: M9U539
• Locus tag: SIRE_RS03210
• Protein ID: WP_014512229.1
• Coordinates: 605312..605659 (-)
• Length: 116 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
SIRE_RS03160 (SiRe_0619)	599817..600641	-	825	WP_014512237.1	DMT family transporter	-
SIRE_RS03165 (SiRe_0620)	600661..600882	-	222	WP_014512236.1	hypothetical protein	-
SIRE_RS14660	600949..601143	-	195	WP_193385884.1	hypothetical protein	-
SIRE_RS03170 (SiRe_0621)	601240..601839	-	600	WP_014512235.1	DUF2249 domain-containing protein	-
SIRE_RS03175 (SiRe_0622)	602087..602314	+	228	WP_014512234.1	hypothetical protein	-
SIRE_RS03180 (SiRe_0623)	602295..602618	-	324	WP_014513667.1	hypothetical protein	-
SIRE_RS03185 (SiRe_0624)	602622..603386	-	765	WP_014512232.1	plastocyanin/azurin family copper-binding protein	-
SIRE_RS14845 (SiRe_0626)	604042..604236	-	195	WP_014513669.1	hypothetical protein	-
SIRE_RS03200 (SiRe_0627)	604361..604636	+	276	WP_014512231.1	hypothetical protein	-
SIRE_RS03205 (SiRe_0628)	604680..605294	-	615	WP_014513670.1	helix-turn-helix domain-containing protein	Toxin
SIRE_RS03210 (SiRe_0629)	605312..605659	-	348	WP_014512229.1	DUF488 domain-containing protein	Antitoxin
SIRE_RS03215 (SiRe_0630)	605728..605958	-	231	WP_014512228.1	C2H2-type zinc finger protein	-
SIRE_RS03220 (SiRe_0631)	606049..606383	+	335	Protein_661	metal-sulfur cluster assembly factor	-
SIRE_RS03225 (SiRe_0632)	606419..607624	-	1206	WP_014513672.1	RNA-guided endonuclease TnpB family protein	-
SIRE_RS03230 (SiRe_0633)	607599..608006	-	408	WP_014513673.1	IS200/IS605 family transposase	-
SIRE_RS03235 (SiRe_0634)	608153..608584	-	432	WP_014513674.1	universal stress protein	-
SIRE_RS03240 (SiRe_0635)	608901..609839	-	939	WP_014512225.1	dipeptidase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Bacterioopsin activator-type, HTH domain (145-197)

Antitoxin

• Protein of unknown function DUF488 (3-108)

Sequences

Toxin

Protein

• Length: 205 a.a.
• Molecular weight: 23379.52 Da
• Isoelectric Point: 9.4585

>T26419 WP_014513670.1 NC_017276:c605294-604680 [Sulfolobus islandicus REY15A]
MLKSPFEVTILIEDHPCEVMGVISSTGLKATVDNVKLGDNTTDHIVLFEKEVQKDDLIKLKSHSIKVLKFNDSKVWVRTK
GCSVCKILYSSNVIVEKIKVIKERTLLYTLLVPNTIAFKEFLANLTSQRIKFTVLSIYEISSNDLTDRQMEILKLAYKMG
YFDDDRRVTLTELAKQLGISTPTLEEIMRRALRKVVKYYLDKVG

Nucleotide

• Length: 615 bp

>T26419 NC_017276:c605294-604680 [Sulfolobus islandicus REY15A]
ATGTTAAAATCACCGTTCGAAGTAACAATCTTGATTGAAGATCACCCTTGTGAGGTTATGGGAGTAATATCTAGTACTGG
GCTTAAAGCAACTGTTGACAACGTTAAACTCGGGGATAATACAACTGATCACATAGTCCTTTTCGAAAAAGAGGTCCAAA
AAGATGATCTAATTAAACTTAAGTCCCATAGTATCAAAGTCTTAAAGTTTAATGATAGCAAAGTATGGGTTAGAACTAAG
GGATGCTCAGTATGTAAGATTCTCTATTCTTCAAATGTTATCGTAGAGAAAATAAAAGTAATAAAAGAGAGAACATTACT
CTATACGCTTTTGGTCCCTAATACGATAGCTTTTAAGGAGTTTCTAGCTAATCTTACTAGTCAAAGGATAAAGTTTACAG
TCCTAAGCATCTATGAAATAAGCAGTAACGACTTAACTGATAGACAAATGGAAATATTGAAACTTGCATACAAGATGGGT
TATTTTGATGATGATAGGAGAGTAACTTTAACTGAATTAGCAAAGCAATTGGGAATATCAACTCCGACTTTGGAGGAAAT
TATGAGGAGAGCGTTAAGGAAAGTCGTCAAGTATTATTTAGATAAAGTAGGGTAA

Antitoxin

Protein

• Length: 116 a.a.
• Molecular weight: 13678.98 Da
• Isoelectric Point: 9.8667

>AT26419 WP_014512229.1 NC_017276:c605659-605312 [Sulfolobus islandicus REY15A]
MIKIKRVYDPIEKDDGLRVLVDRLWPRGIGKNKVDLWLKDIAPSDELRKWYGHDASKWDEFKRKYFEELDANPKMSILLQ
LIRKGENITLLYASKSPYNNAIALKEYLEKKILKE

Nucleotide

• Length: 348 bp

>AT26419 NC_017276:c605659-605312 [Sulfolobus islandicus REY15A]
ATGATTAAGATAAAGAGGGTTTACGATCCAATAGAGAAAGATGACGGACTAAGAGTCTTAGTGGATAGGTTATGGCCAAG
AGGAATTGGCAAAAATAAGGTGGATTTATGGCTTAAAGATATAGCACCCAGTGATGAGTTACGAAAATGGTACGGTCATG
ATGCCAGTAAATGGGATGAGTTCAAAAGGAAATATTTTGAGGAACTAGATGCTAATCCAAAGATGAGTATTTTATTACAA
TTAATTAGAAAGGGCGAAAATATTACCTTACTTTACGCCTCCAAATCACCGTATAATAATGCAATTGCGTTAAAGGAGTA
TCTAGAGAAAAAGATATTAAAAGAATAG

Structures

Toxin

• AlphaFold DB: F0NEE9

Antitoxin

• AlphaFold DB: M9U539