264187

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-PHD
Location 3829641..3830326 Replicon chromosome
Accession NZ_CP110674
Organism Mycobacterium tuberculosis strain BLR-31d

Toxin (Protein)


Gene name vapC Uniprot ID G0TIR9
Locus tag OO115_RS17970 Protein ID WP_003417998.1
Coordinates 3829916..3830326 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag OO115_RS17965 Protein ID WP_180895138.1
Coordinates 3829641..3829919 (+) Length 93 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OO115_RS17945 (OO115_17945) 3825630..3827231 - 1602 WP_003417969.1 FAD/NAD(P)-binding protein -
OO115_RS17950 (OO115_17950) 3827248..3827952 - 705 WP_003417980.1 dTDP-4-amino-4,6-dideoxyglucose formyltransferase -
OO115_RS17955 (OO115_17955) 3828070..3828636 - 567 WP_003417984.1 TetR/AcrR family transcriptional regulator -
OO115_RS17960 (OO115_17960) 3828698..3829585 + 888 WP_003900050.1 alpha-ketoglutarate-dependent sulfate ester dioxygenase -
OO115_RS17965 (OO115_17965) 3829641..3829919 + 279 WP_180895138.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
OO115_RS17970 (OO115_17970) 3829916..3830326 + 411 WP_003417998.1 type II toxin-antitoxin system VapC family toxin Toxin
OO115_RS17975 (OO115_17975) 3830359..3832095 - 1737 WP_003418002.1 cholesterol oxidase -
OO115_RS17980 (OO115_17980) 3832151..3833278 - 1128 WP_003418005.1 GuaB3 family IMP dehydrogenase-related protein -
OO115_RS17985 (OO115_17985) 3833298..3834887 - 1590 WP_003901630.1 IMP dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-118)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(3-58)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 14695.84 Da        Isoelectric Point: 5.1784

>T264187 WP_003417998.1 NZ_CP110674:3829916-3830326 [Mycobacterium tuberculosis]
VIYMDTSALTKLLISEPETTELRTWLTAQSGQGEDAATSTLGRVELMRVVARYGQPGQTERARYLLDGLDILPLTEPVIG
LAETIGPATLRSLDAIHLAAAAQIKRELTAFVTYDHRLLSGCREVGFVTASPGAVR

Download         Length: 411 bp

Antitoxin


Download         Length: 93 a.a.        Molecular weight: 10227.70 Da        Isoelectric Point: 8.0222

>AT264187 WP_180895138.1 NZ_CP110674:3829641-3829919 [Mycobacterium tuberculosis]
VEAIGIRELRQHASRYLARVEAGEELGVTNKGRLVARLIPVQAAERSREALIESGVLIPARRPQNLLDVTAEPARGCKRT
LSDVLNEMRDEQ

Download         Length: 279 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0TIR9

Antitoxin

Source ID Structure

References