264185

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/Txe-YefM
Location 3773511..3774040 Replicon chromosome
Accession NZ_CP110674
Organism Mycobacterium tuberculosis strain BLR-31d

Toxin (Protein)


Gene name relE Uniprot ID G0TI95
Locus tag OO115_RS17705 Protein ID WP_003417760.1
Coordinates 3773783..3774040 (+) Length 86 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID G0TI94
Locus tag OO115_RS17700 Protein ID WP_003417757.1
Coordinates 3773511..3773786 (+) Length 92 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OO115_RS17665 (OO115_17665) 3770084..3770773 - 690 WP_003917774.1 BBE domain-containing protein -
OO115_RS17670 (OO115_17670) 3770960..3771331 - 372 WP_003417739.1 FAD-binding protein -
OO115_RS17675 (OO115_17675) 3771229..3771447 - 219 WP_157132559.1 hypothetical protein -
OO115_RS17680 (OO115_17680) 3771474..3771734 - 261 WP_003417741.1 hypothetical protein -
OO115_RS17685 (OO115_17685) 3771849..3772238 + 390 WP_003417745.1 DUF732 domain-containing protein -
OO115_RS17690 (OO115_17690) 3772252..3772545 - 294 WP_003417749.1 DUF3017 domain-containing protein -
OO115_RS17695 (OO115_17695) 3772542..3773387 - 846 WP_003417751.1 bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase -
OO115_RS17700 (OO115_17700) 3773511..3773786 + 276 WP_003417757.1 type II toxin-antitoxin system antitoxin RelJ Antitoxin
OO115_RS17705 (OO115_17705) 3773783..3774040 + 258 WP_003417760.1 Txe/YoeB family addiction module toxin Toxin
OO115_RS17710 (OO115_17710) 3774082..3775272 + 1191 WP_003900033.1 NADH:flavin oxidoreductase -
OO115_RS17715 (OO115_17715) 3775389..3775757 + 369 WP_003417765.1 FHA domain-containing protein -
OO115_RS17720 (OO115_17720) 3775754..3776305 - 552 WP_003417767.1 pentapeptide repeat protein MfpA -
OO115_RS17725 (OO115_17725) 3776312..3776893 - 582 WP_003417769.1 ATP/GTP-binding protein -
OO115_RS17730 (OO115_17730) 3776874..3777242 - 369 WP_003417772.1 DUF742 domain-containing protein -
OO115_RS17735 (OO115_17735) 3777220..3777612 - 393 WP_003417776.1 serine protease inhibitor -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(6-85)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(2-72)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 10070.30 Da        Isoelectric Point: 6.4693

>T264185 WP_003417760.1 NZ_CP110674:3773783-3774040 [Mycobacterium tuberculosis]
VRSVNFDPDAWEDFLFWLAADRKTARRITRLIGEIQRDPFSGIGKPEPLQGELSGYWSRRIDDEHRLVYRAGDDEVTMLK
ARYHY

Download         Length: 258 bp

Antitoxin


Download         Length: 92 a.a.        Molecular weight: 10194.35 Da        Isoelectric Point: 4.6652

>AT264185 WP_003417757.1 NZ_CP110674:3773511-3773786 [Mycobacterium tuberculosis]
MSISASEARQRLFPLIEQVNTDHQPVRITSRAGDAVLMSADDYDAWQETVYLLRSPENARRLMEAVARDKAGHSAFTKSV
DELREMAGGEE

Download         Length: 276 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 3OEI

Antitoxin

Source ID Structure
AlphaFold DB G0TI94

References