264184

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 3702976..3703601 Replicon chromosome
Accession NZ_CP110674
Organism Mycobacterium tuberculosis strain BLR-31d

Toxin (Protein)


Gene name vapC Uniprot ID G0TQA0
Locus tag OO115_RS17490 Protein ID WP_003403218.1
Coordinates 3702976..3703377 (-) Length 134 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID P9WJ36
Locus tag OO115_RS17495 Protein ID WP_003403213.1
Coordinates 3703374..3703601 (-) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OO115_RS17465 (OO115_17465) 3698066..3699013 - 948 WP_003403232.1 DUF732 domain-containing protein -
OO115_RS17470 (OO115_17470) 3699117..3700181 - 1065 WP_003898532.1 zinc ribbon domain-containing protein -
OO115_RS17475 (OO115_17475) 3700576..3701667 - 1092 WP_003900977.1 galactokinase -
OO115_RS17480 (OO115_17480) 3701664..3702745 - 1082 Protein_3452 galactose-1-phosphate uridylyltransferase -
OO115_RS17485 (OO115_17485) 3702764..3702847 - 84 Protein_3453 galactose-1-phosphate uridylyltransferase -
OO115_RS17490 (OO115_17490) 3702976..3703377 - 402 WP_003403218.1 type II toxin-antitoxin system ribonuclease VapC29 Toxin
OO115_RS17495 (OO115_17495) 3703374..3703601 - 228 WP_003403213.1 antitoxin VapB29 Antitoxin
OO115_RS17500 (OO115_17500) 3703796..3704038 - 243 WP_003403210.1 hypothetical protein -
OO115_RS17505 (OO115_17505) 3704035..3704784 - 750 WP_003898528.1 hypothetical protein -
OO115_RS17510 (OO115_17510) 3704868..3707435 + 2568 WP_003901879.1 SEC-C metal-binding domain-containing protein -
OO115_RS17515 (OO115_17515) 3707454..3708059 - 606 WP_003898526.1 hypothetical protein -
OO115_RS17520 (OO115_17520) 3708201..3708422 + 222 WP_003898525.1 DUF4926 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(3-120)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 134 a.a.        Molecular weight: 13937.76 Da        Isoelectric Point: 5.7441

>T264184 WP_003403218.1 NZ_CP110674:c3703377-3702976 [Mycobacterium tuberculosis]
VTVLLDANVLIALVVAEHVHHDAAADWLMASDTGFATCPMTQGSLVRFLVRSGQSAAAARDVVSAVQCTSRHEFWPDALS
FAGVEVAGVVGHRQVTDAYLAQLARSHDGQLATLDSGLAHLHGDVAVLIPTTT

Download         Length: 402 bp

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8163.17 Da        Isoelectric Point: 5.6307

>AT264184 WP_003403213.1 NZ_CP110674:c3703601-3703374 [Mycobacterium tuberculosis]
VRTTIDLPQDLHKQALAIARDTHRTLSETVADLMRRGLAANRPTALSSDPRTGLPLVSVGTVVTSEDVRSLEDEQ

Download         Length: 228 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0TQA0

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4BSC9

References