264183

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC(toxin)
Location 3697324..3697973 Replicon chromosome
Accession NZ_CP110674
Organism Mycobacterium tuberculosis strain BLR-31d

Toxin (Protein)


Gene name vapC Uniprot ID P67241
Locus tag OO115_RS17455 Protein ID WP_003403236.1
Coordinates 3697324..3697719 (-) Length 132 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID P9WJ34
Locus tag OO115_RS17460 Protein ID WP_003403235.1
Coordinates 3697719..3697973 (-) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OO115_RS17430 (OO115_17430) 3692651..3694378 + 1728 WP_003901883.1 exodeoxyribonuclease V subunit alpha -
OO115_RS17435 (OO115_17435) 3694471..3695622 + 1152 WP_003403248.1 FIST N-terminal domain-containing protein -
OO115_RS17440 (OO115_17440) 3695694..3696101 - 408 WP_003403246.1 type II toxin-antitoxin system VapC family toxin -
OO115_RS17445 (OO115_17445) 3696098..3696358 - 261 WP_003403244.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
OO115_RS17450 (OO115_17450) 3696490..3697230 + 741 WP_003403239.1 TVP38/TMEM64 family protein -
OO115_RS17455 (OO115_17455) 3697324..3697719 - 396 WP_003403236.1 type II toxin-antitoxin system toxin ribonuclease C30 Toxin
OO115_RS17460 (OO115_17460) 3697719..3697973 - 255 WP_003403235.1 type II toxin-antitoxin system antitoxin VapB30 Antitoxin
OO115_RS17465 (OO115_17465) 3698066..3699013 - 948 WP_003403232.1 DUF732 domain-containing protein -
OO115_RS17470 (OO115_17470) 3699117..3700181 - 1065 WP_003898532.1 zinc ribbon domain-containing protein -
OO115_RS17475 (OO115_17475) 3700576..3701667 - 1092 WP_003900977.1 galactokinase -
OO115_RS17480 (OO115_17480) 3701664..3702745 - 1082 Protein_3452 galactose-1-phosphate uridylyltransferase -
OO115_RS17485 (OO115_17485) 3702764..3702847 - 84 Protein_3453 galactose-1-phosphate uridylyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(1-124)

Antitoxin

Antitoxin VapB-like

(1-83)


Sequences

Toxin        


Download         Length: 132 a.a.        Molecular weight: 14250.04 Da        Isoelectric Point: 4.7475

>T264183 WP_003403236.1 NZ_CP110674:c3697719-3697324 [Mycobacterium tuberculosis]
MVIDTSALVAMLSDEPDAERFEAAVEADHIRLMSTASYLETALVIEARFGEPGGRELDLWLHRAAVDLVAVHADQADAAR
AAYRTYGKGRHRAGLNYGDCFSYGLAKISGQPLLFKGEDFQHTDIATVALP

Download         Length: 396 bp

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9139.52 Da        Isoelectric Point: 9.2702

>AT264183 WP_003403235.1 NZ_CP110674:c3697973-3697719 [Mycobacterium tuberculosis]
MALSIKHPEADRLARALAARTGETLTEAVVTALRERLARETGRARVVPLRDELAAIRHRCAALPVVDNRSAEAILGYDER
GLPA

Download         Length: 255 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4XGR
PDB 4XGQ

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4BSC2

References