26418

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 366556..367162 Replicon chromosome
Accession NC_017276
Organism Sulfolobus islandicus REY15A

Toxin (Protein)


Gene name vapC Uniprot ID F0NGC1
Locus tag SIRE_RS02045 Protein ID WP_014513533.1
Coordinates 366556..366918 (-) Length 121 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID M9UCL5
Locus tag SIRE_RS02050 Protein ID WP_012718013.1
Coordinates 366941..367162 (-) Length 74 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SIRE_RS02030 (SiRe_0399) 362417..363814 - 1398 WP_014512473.1 glycosyltransferase -
SIRE_RS02035 (SiRe_0400) 363859..364452 - 594 WP_012718017.1 hypothetical protein -
SIRE_RS02040 (SiRe_0401) 364544..366097 + 1554 WP_014513532.1 aldehyde dehydrogenase family protein -
SIRE_RS02045 (SiRe_0402) 366556..366918 - 363 WP_014513533.1 type II toxin-antitoxin system VapC family toxin Toxin
SIRE_RS02050 (SiRe_0403) 366941..367162 - 222 WP_012718013.1 hypothetical protein Antitoxin
SIRE_RS02055 367628..367964 - 337 Protein_417 transposase -
SIRE_RS02060 (SiRe_0404) 368007..369238 - 1232 Protein_418 IS256 family transposase -
SIRE_RS02070 369335..369595 - 261 Protein_419 IS5/IS1182 family transposase -
SIRE_RS02075 (SiRe_0405) 369729..370289 - 561 WP_014513534.1 PIG-L deacetylase family protein -
SIRE_RS02080 (SiRe_0406) 370294..371439 - 1146 WP_014513535.1 glycosyltransferase -
SIRE_RS02085 (SiRe_0407) 371594..372127 + 534 WP_012713047.1 ADP-ribose-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Pae0151-like, PIN domain

(21-113)

Antitoxin

Putative antitoxin VapB3-like

(1-73)


Sequences

Toxin        


Download         Length: 121 a.a.        Molecular weight: 13856.19 Da        Isoelectric Point: 9.2430

>T26418 WP_014513533.1 NC_017276:c366918-366556 [Sulfolobus islandicus REY15A]
VTKEKGWNRITELLKDSETLDLALVEVSNVIWKKVVLTNEITPQDANKAIMIVKEYLPQLLTVNKSVKLLERAIDISIRE
KLTIYDSLYIALAESKRSKLLTSDKKQYEVARKYVDSELF

Download         Length: 363 bp

>T26418 NC_017276:c366918-366556 [Sulfolobus islandicus REY15A]
GTGACTAAGGAGAAGGGATGGAATAGAATTACGGAGTTACTAAAGGATAGTGAAACTCTAGATCTGGCGCTAGTAGAAGT
TTCCAATGTTATTTGGAAGAAAGTGGTGTTAACAAACGAGATTACTCCACAGGATGCCAATAAGGCGATTATGATTGTTA
AGGAATATCTACCTCAATTGCTGACTGTAAATAAAAGCGTTAAACTCTTGGAAAGAGCTATAGATATCTCTATAAGGGAA
AAACTGACTATATACGACTCGCTATATATTGCCTTAGCGGAAAGCAAGAGAAGTAAATTATTAACCAGCGATAAAAAGCA
ATATGAGGTTGCAAGAAAATACGTGGACTCGGAATTATTTTAG

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 8952.22 Da        Isoelectric Point: 4.6475

>AT26418 WP_012718013.1 NC_017276:c367162-366941 [Sulfolobus islandicus REY15A]
MKMVYSLRIDKELREEMEKYDIKWNEEIEGFIRKRLEELKKEEILKRINEILSTMPETNSSSAEMVREDRDNN

Download         Length: 222 bp

>AT26418 NC_017276:c367162-366941 [Sulfolobus islandicus REY15A]
ATGAAAATGGTATACAGTTTAAGGATAGATAAAGAATTACGTGAGGAGATGGAAAAGTACGACATAAAGTGGAATGAAGA
GATAGAGGGTTTCATAAGGAAAAGGCTTGAGGAATTGAAAAAAGAGGAGATTCTAAAGAGGATTAATGAGATCCTTTCAA
CCATGCCGGAAACTAATTCAAGTAGTGCGGAAATGGTGAGGGAAGATAGGGATAATAATTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB F0NGC1

Antitoxin

Source ID Structure
AlphaFold DB M9UCL5

References