Detailed information of TA system TA026418

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/PIN(toxin)
• Location: 366556..367162
• Replicon: chromosome
• Accession: NC_017276
• Organism: Sulfolobus islandicus REY15A

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: F0NGC1
• Locus tag: SIRE_RS02045
• Protein ID: WP_014513533.1
• Coordinates: 366556..366918 (-)
• Length: 121 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: M9UCL5
• Locus tag: SIRE_RS02050
• Protein ID: WP_012718013.1
• Coordinates: 366941..367162 (-)
• Length: 74 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
SIRE_RS02030 (SiRe_0399)	362417..363814	-	1398	WP_014512473.1	glycosyltransferase	-
SIRE_RS02035 (SiRe_0400)	363859..364452	-	594	WP_012718017.1	hypothetical protein	-
SIRE_RS02040 (SiRe_0401)	364544..366097	+	1554	WP_014513532.1	aldehyde dehydrogenase family protein	-
SIRE_RS02045 (SiRe_0402)	366556..366918	-	363	WP_014513533.1	type II toxin-antitoxin system VapC family toxin	Toxin
SIRE_RS02050 (SiRe_0403)	366941..367162	-	222	WP_012718013.1	hypothetical protein	Antitoxin
SIRE_RS02055	367628..367964	-	337	Protein_417	transposase	-
SIRE_RS02060 (SiRe_0404)	368007..369238	-	1232	Protein_418	IS256 family transposase	-
SIRE_RS02070	369335..369595	-	261	Protein_419	IS5/IS1182 family transposase	-
SIRE_RS02075 (SiRe_0405)	369729..370289	-	561	WP_014513534.1	PIG-L deacetylase family protein	-
SIRE_RS02080 (SiRe_0406)	370294..371439	-	1146	WP_014513535.1	glycosyltransferase	-
SIRE_RS02085 (SiRe_0407)	371594..372127	+	534	WP_012713047.1	ADP-ribose-binding protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Pae0151-like, PIN domain (21-113)

Antitoxin

• Putative antitoxin VapB3-like (1-73)

Sequences

Toxin

Protein

• Length: 121 a.a.
• Molecular weight: 13856.19 Da
• Isoelectric Point: 9.2430

>T26418 WP_014513533.1 NC_017276:c366918-366556 [Sulfolobus islandicus REY15A]
VTKEKGWNRITELLKDSETLDLALVEVSNVIWKKVVLTNEITPQDANKAIMIVKEYLPQLLTVNKSVKLLERAIDISIRE
KLTIYDSLYIALAESKRSKLLTSDKKQYEVARKYVDSELF

Nucleotide

• Length: 363 bp

>T26418 NC_017276:c366918-366556 [Sulfolobus islandicus REY15A]
GTGACTAAGGAGAAGGGATGGAATAGAATTACGGAGTTACTAAAGGATAGTGAAACTCTAGATCTGGCGCTAGTAGAAGT
TTCCAATGTTATTTGGAAGAAAGTGGTGTTAACAAACGAGATTACTCCACAGGATGCCAATAAGGCGATTATGATTGTTA
AGGAATATCTACCTCAATTGCTGACTGTAAATAAAAGCGTTAAACTCTTGGAAAGAGCTATAGATATCTCTATAAGGGAA
AAACTGACTATATACGACTCGCTATATATTGCCTTAGCGGAAAGCAAGAGAAGTAAATTATTAACCAGCGATAAAAAGCA
ATATGAGGTTGCAAGAAAATACGTGGACTCGGAATTATTTTAG

Antitoxin

Protein

• Length: 74 a.a.
• Molecular weight: 8952.22 Da
• Isoelectric Point: 4.6475

>AT26418 WP_012718013.1 NC_017276:c367162-366941 [Sulfolobus islandicus REY15A]
MKMVYSLRIDKELREEMEKYDIKWNEEIEGFIRKRLEELKKEEILKRINEILSTMPETNSSSAEMVREDRDNN

Nucleotide

• Length: 222 bp

>AT26418 NC_017276:c367162-366941 [Sulfolobus islandicus REY15A]
ATGAAAATGGTATACAGTTTAAGGATAGATAAAGAATTACGTGAGGAGATGGAAAAGTACGACATAAAGTGGAATGAAGA
GATAGAGGGTTTCATAAGGAAAAGGCTTGAGGAATTGAAAAAAGAGGAGATTCTAAAGAGGATTAATGAGATCCTTTCAA
CCATGCCGGAAACTAATTCAAGTAGTGCGGAAATGGTGAGGGAAGATAGGGATAATAATTGA

Structures

Toxin

• AlphaFold DB: F0NGC1

Antitoxin

• AlphaFold DB: M9UCL5