Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapC-mazE/PIN(toxin)
Location 3658078..3658870 Replicon chromosome
Accession NZ_CP110674
Organism Mycobacterium tuberculosis strain BLR-31d

Toxin (Protein)


Gene name vapC Uniprot ID P9WFB2
Locus tag OO115_RS17245 Protein ID WP_003403386.1
Coordinates 3658078..3658515 (+) Length 146 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID G0TQE0
Locus tag OO115_RS17250 Protein ID WP_003403381.1
Coordinates 3658625..3658870 (+) Length 82 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OO115_RS17220 (OO115_17220) 3654541..3654714 - 174 WP_003898549.1 hypothetical protein -
OO115_RS17225 (OO115_17225) 3654711..3655049 - 339 WP_003403405.1 PIN domain-containing protein -
OO115_RS17230 (OO115_17230) 3654961..3655287 - 327 WP_003403401.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
OO115_RS17235 (OO115_17235) 3655350..3657713 - 2364 WP_003901895.1 arylsulfatase AtsD -
OO115_RS17240 (OO115_17240) 3657827..3658081 + 255 WP_003911263.1 antitoxin VapB7 -
OO115_RS17245 (OO115_17245) 3658078..3658515 + 438 WP_003403386.1 type II toxin-antitoxin system VapC family toxin Toxin
OO115_RS17250 (OO115_17250) 3658625..3658870 + 246 WP_003403381.1 ribbon-helix-helix protein, CopG family Antitoxin
OO115_RS17255 (OO115_17255) 3658857..3659165 + 309 WP_003403376.1 type II toxin-antitoxin system PemK/MazF family toxin -
OO115_RS17260 (OO115_17260) 3659441..3660157 + 717 WP_003403371.1 CPBP family intramembrane metalloprotease -
OO115_RS17265 (OO115_17265) 3660233..3660388 + 156 WP_003403368.1 type II toxin-antitoxin system VapB family antitoxin -
OO115_RS17270 (OO115_17270) 3660483..3660866 + 384 WP_003403365.1 ribonuclease VapC6 -
OO115_RS17275 (OO115_17275) 3661254..3662264 - 1011 WP_003911248.1 ABC transporter ATP-binding protein -
OO115_RS17280 (OO115_17280) 3662345..3663850 - 1506 WP_003403360.1 carotenoid cleavage oxygenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-126)

Antitoxin

Ribbon-helix-helix protein, CopG

(2-38)


Sequences

Toxin        


Download         Length: 146 a.a.        Molecular weight: 15245.39 Da        Isoelectric Point: 5.1865

>T264179 WP_003403386.1 NZ_CP110674:3658078-3658515 [Mycobacterium tuberculosis]
MIVLDTTVLVYAKGAEHPLRDPCRDLVAAIADERIAATTTAEVIQEFVHVRARRRDRSDAAALGRVTMPNCSRRYSPSIE
ATSKRGLTLFETTPGLEACDAVLAAVAASAGATALVSADPAFADLSDVVHVIPDAAGMVSLLGDR

Download         Length: 438 bp

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 9169.01 Da        Isoelectric Point: 4.2070

>AT264179 WP_003403381.1 NZ_CP110674:3658625-3658870 [Mycobacterium tuberculosis]
MLSFRADDHDVDLADAWARRLHIGRSELLRDALRRHLAALAADQDVQAYTERPLTDDENALAEIADWGPAEDWADWADAA
R

Download         Length: 246 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U4BSW5

Antitoxin

Source ID Structure
AlphaFold DB G0TQE0

References