Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 3572213..3572922 Replicon chromosome
Accession NZ_CP110674
Organism Mycobacterium tuberculosis strain BLR-31d

Toxin (Protein)


Gene name vapC Uniprot ID P9WF74
Locus tag OO115_RS16770 Protein ID WP_003403837.1
Coordinates 3572213..3572641 (-) Length 143 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID G0TEX4
Locus tag OO115_RS16775 Protein ID WP_003403834.1
Coordinates 3572665..3572922 (-) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OO115_RS16745 (OO115_16745) 3567916..3569448 + 1533 WP_003403847.1 CoA-acylating methylmalonate-semialdehyde dehydrogenase -
OO115_RS16750 (OO115_16750) 3569455..3570627 + 1173 WP_003403845.1 acyl-CoA dehydrogenase family protein -
OO115_RS16755 (OO115_16755) 3570638..3571522 + 885 WP_003403844.1 3-hydroxyisobutyrate dehydrogenase -
OO115_RS16760 (OO115_16760) 3571591..3571836 - 246 WP_003403841.1 hypothetical protein -
OO115_RS16765 (OO115_16765) 3571995..3572132 + 138 WP_003403839.1 hypothetical protein -
OO115_RS16770 (OO115_16770) 3572213..3572641 - 429 WP_003403837.1 type II toxin-antitoxin system VapC family toxin Toxin
OO115_RS16775 (OO115_16775) 3572665..3572922 - 258 WP_003403834.1 ribbon-helix-helix protein, CopG family Antitoxin
OO115_RS16780 (OO115_16780) 3573013..3575286 - 2274 WP_016330384.1 PE family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain toxin

(1-141)

Antitoxin

Ribbon-helix-helix protein, CopG

(2-36)


Sequences

Toxin        


Download         Length: 143 a.a.        Molecular weight: 15831.27 Da        Isoelectric Point: 7.5536

>T264177 WP_003403837.1 NZ_CP110674:c3572641-3572213 [Mycobacterium tuberculosis]
MFLLDANVLLAAHRGDHPNHRTVRPWFDRLLAADDPFTVPNLVWASFLRLATNRRIFEIPSPRAEAFAFVEAVTAQPHHL
PTNPGPRHLMLLRKLCDEADASGDLIPDAVLAAIAVGHHCAVVSLDRDFARFASVRHIRPPL

Download         Length: 429 bp

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9114.28 Da        Isoelectric Point: 10.6530

>AT264177 WP_003403834.1 NZ_CP110674:c3572922-3572665 [Mycobacterium tuberculosis]
MRTTVSISDEILAAAKRRARERGQSLGAVIEDALRREFAAAHVGGARPTVPVFDGGTGPRRGIDLTSNRALSEVLDEGLE
LNSRK

Download         Length: 258 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829CDR3

Antitoxin

Source ID Structure
AlphaFold DB G0TEX4

References