264176

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) unclassified/Polyketide_cyc2(toxin)
Location 3398826..3399445 Replicon chromosome
Accession NZ_CP110674
Organism Mycobacterium tuberculosis strain BLR-31d

Toxin (Protein)


Gene name novel[antitoxin] Uniprot ID -
Locus tag OO115_RS15930 Protein ID WP_003404726.1
Coordinates 3398826..3399260 (-) Length 145 a.a.

Antitoxin (Protein)


Gene name novel[toxin] Uniprot ID P9WJ06
Locus tag OO115_RS15935 Protein ID WP_003898641.1
Coordinates 3399266..3399445 (-) Length 60 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OO115_RS15905 (OO115_15905) 3394161..3395399 + 1239 WP_003404744.1 acetyl-CoA acetyltransferase -
OO115_RS15910 (OO115_15910) 3395401..3396909 + 1509 WP_003404742.1 carotenoid oxygenase family protein -
OO115_RS15915 (OO115_15915) 3397076..3397306 + 231 WP_003898642.1 hypothetical protein -
OO115_RS15920 (OO115_15920) 3397441..3397890 - 450 WP_003404738.1 hypothetical protein -
OO115_RS15925 (OO115_15925) 3397955..3398728 - 774 WP_003404735.1 VOC family protein -
OO115_RS15930 (OO115_15930) 3398826..3399260 - 435 WP_003404726.1 SRPBCC family protein Toxin
OO115_RS15935 (OO115_15935) 3399266..3399445 - 180 WP_003898641.1 antitoxin Antitoxin
OO115_RS15940 (OO115_15940) 3399571..3399729 - 159 WP_003404720.1 hypothetical protein -
OO115_RS15945 (OO115_15945) 3400002..3402395 - 2394 WP_003898639.1 cation-translocating P-type ATPase -
OO115_RS15950 (OO115_15950) 3402392..3403972 - 1581 WP_003910977.1 serine hydrolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Polyketide cyclase/dehydrase

(1-142)

Antitoxin

Antitoxin Rv0909/MT0933

(4-50)


Sequences

Toxin        


Download         Length: 145 a.a.        Molecular weight: 15754.47 Da        Isoelectric Point: 9.7977

>T264176 WP_003404726.1 NZ_CP110674:c3399260-3398826 [Mycobacterium tuberculosis]
MAKLSGSIDVPLPPEEAWMHASDLTRYREWLTIHKVWRSKLPEVLEKGTVVESYVEVKGMPNRIKWTIVRYKPPEGMTLN
GDGVGGVKVKLIAKVAPKEHGSVVSFDVHLGGPALLGPIGMIVAAALRADIRESLQNFVTVFAG

Download         Length: 435 bp

Antitoxin


Download         Length: 60 a.a.        Molecular weight: 6403.07 Da        Isoelectric Point: 4.5393

>AT264176 WP_003898641.1 NZ_CP110674:c3399445-3399266 [Mycobacterium tuberculosis]
MGILDKVKNLLSQNADKVETVINKAGEFVDEQTQGNYSDAIHKLHDAASNVVGMSDQQS

Download         Length: 180 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A045KDK5

References