264174

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 3182665..3183296 Replicon chromosome
Accession NZ_CP110674
Organism Mycobacterium tuberculosis strain BLR-31d

Toxin (Protein)


Gene name mazF Uniprot ID A0A7U4F9D0
Locus tag OO115_RS14875 Protein ID WP_003405820.1
Coordinates 3182985..3183296 (+) Length 104 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID G0TGZ7
Locus tag OO115_RS14870 Protein ID WP_003405836.1
Coordinates 3182665..3182985 (+) Length 107 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OO115_RS14845 (OO115_14845) 3177861..3178499 + 639 WP_003898730.1 lipid droplet-associated protein -
OO115_RS14850 (OO115_14850) 3178496..3179743 + 1248 WP_003405846.1 exodeoxyribonuclease VII large subunit -
OO115_RS14855 (OO115_14855) 3179733..3179990 + 258 WP_003405844.1 exodeoxyribonuclease VII small subunit -
OO115_RS14860 (OO115_14860) 3180000..3181112 + 1113 WP_003405840.1 3 beta-hydroxysteroid dehydrogenase/delta 5-->4-isomerase -
OO115_RS14865 (OO115_14865) 3181119..3182655 - 1537 Protein_2941 carboxylesterase/lipase family protein -
OO115_RS14870 (OO115_14870) 3182665..3182985 + 321 WP_003405836.1 type II toxin-antitoxin system antitoxin MazE3 Antitoxin
OO115_RS14875 (OO115_14875) 3182985..3183296 + 312 WP_003405820.1 type II toxin-antitoxin system toxin endoribonuclease MazF3 Toxin
OO115_RS14880 (OO115_14880) 3183408..3184565 + 1158 WP_003898727.1 AI-2E family transporter -
OO115_RS14885 (OO115_14885) 3184572..3185216 - 645 WP_003915494.1 DUF4245 domain-containing protein -
OO115_RS14890 (OO115_14890) 3185272..3186360 + 1089 WP_003898726.1 class II fructose-bisphosphatase -
OO115_RS14895 (OO115_14895) 3186391..3187815 + 1425 WP_003405805.1 class II fumarate hydratase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(8-85)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 11061.82 Da        Isoelectric Point: 4.9371

>T264174 WP_003405820.1 NZ_CP110674:3182985-3183296 [Mycobacterium tuberculosis]
MRPIHIAQLDKARPVLILTREVVRPHLTNVTVAPITTTVRGLATEVPVDAVNGLNQPSVVSCDNIQTIPVCDLGRQIGYL
LASQEPALAEAIGNAFDLDWVVA

Download         Length: 312 bp

Antitoxin


Download         Length: 107 a.a.        Molecular weight: 11394.83 Da        Isoelectric Point: 5.1236

>AT264174 WP_003405836.1 NZ_CP110674:3182665-3182985 [Mycobacterium tuberculosis]
MYLPWGVVLAGGANGFGAGAYQTGTICEVSTQIAVRLPDEIVAFIDDEVRGQHARSRAAVVLRALERERRRRLAERDAEI
LATNTSATGDLDTLAGHCARTALDID

Download         Length: 321 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U4F9D0

Antitoxin

Source ID Structure
AlphaFold DB G0TGZ7

References