264173

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VapB
Location 3173972..3174540 Replicon chromosome
Accession NZ_CP110674
Organism Mycobacterium tuberculosis strain BLR-31d

Toxin (Protein)


Gene name vapC Uniprot ID G0TH08
Locus tag OO115_RS14820 Protein ID WP_003405865.1
Coordinates 3173972..3174346 (-) Length 125 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID G0TH07
Locus tag OO115_RS14825 Protein ID WP_003405863.1
Coordinates 3174343..3174540 (-) Length 66 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OO115_RS14785 (OO115_14785) 3170322..3171092 + 771 Protein_2925 adenylate/guanylate cyclase domain-containing protein -
OO115_RS14790 (OO115_14790) 3171044..3171253 - 210 WP_003911400.1 hypothetical protein -
OO115_RS14795 (OO115_14795) 3171287..3171985 + 699 WP_031646953.1 hypothetical protein -
OO115_RS14800 (OO115_14800) 3172000..3172323 - 324 WP_003405871.1 putative quinol monooxygenase -
OO115_RS14805 (OO115_14805) 3172566..3172841 + 276 WP_003405867.1 hypothetical protein -
OO115_RS14810 (OO115_14810) 3172768..3172953 - 186 WP_003901093.1 hypothetical protein -
OO115_RS14815 (OO115_14815) 3173071..3173769 - 699 WP_003898733.1 hypothetical protein -
OO115_RS14820 (OO115_14820) 3173972..3174346 - 375 WP_003405865.1 type II toxin-antitoxin system VapC family toxin Toxin
OO115_RS14825 (OO115_14825) 3174343..3174540 - 198 WP_003405863.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
OO115_RS14830 (OO115_14830) 3174628..3175701 - 1074 WP_003898732.1 redox-regulated ATPase YchF -
OO115_RS14835 (OO115_14835) 3175764..3176747 + 984 WP_003898731.1 hypothetical protein -
OO115_RS14840 (OO115_14840) 3176764..3177771 - 1008 WP_003405853.1 4-hydroxy-3-methylbut-2-enyl diphosphate reductase -
OO115_RS14845 (OO115_14845) 3177861..3178499 + 639 WP_003898730.1 lipid droplet-associated protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-111)

Antitoxin

Bacterial antitoxin of type II TA system, VapB

(1-42)


Sequences

Toxin        


Download         Length: 125 a.a.        Molecular weight: 13444.56 Da        Isoelectric Point: 5.1881

>T264173 WP_003405865.1 NZ_CP110674:c3174346-3173972 [Mycobacterium tuberculosis]
VILVDTSVWIEHLRAADARLVELLGDDEAGCHPLVIEELALGSIKQRDVVLDLLANLYQFPVVTHDEVLRLVGRRRLWGR
GLGAVDANLLGSVALVGGARLWTRDKRLKAACAESGVALAEEVS

Download         Length: 375 bp

Antitoxin


Download         Length: 66 a.a.        Molecular weight: 6973.03 Da        Isoelectric Point: 11.7327

>AT264173 WP_003405863.1 NZ_CP110674:c3174540-3174343 [Mycobacterium tuberculosis]
MRTTVTVDDALLAKAAELTGVKEKSTLLREGLQTLVRVESARRLAALGGTDPQATAAPRRRTSPR

Download         Length: 198 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0TH08

Antitoxin

Source ID Structure
AlphaFold DB G0TH07

References