264172

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 2951609..2952296 Replicon chromosome
Accession NZ_CP110674
Organism Mycobacterium tuberculosis strain BLR-31d

Toxin (Protein)


Gene name vapC Uniprot ID P65044
Locus tag OO115_RS13915 Protein ID WP_003414624.1
Coordinates 2951853..2952296 (+) Length 148 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID G0TFH0
Locus tag OO115_RS13910 Protein ID WP_003414620.1
Coordinates 2951609..2951866 (+) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OO115_RS13890 (OO115_13890) 2946929..2947783 - 855 WP_003899516.1 GNAT family N-acetyltransferase -
OO115_RS13895 (OO115_13895) 2947839..2949002 - 1164 WP_003899517.1 flavodoxin-dependent (E)-4-hydroxy-3-methylbut-2-enyl-diphosphate synthase -
OO115_RS13900 (OO115_13900) 2949019..2950233 - 1215 WP_003414610.1 zinc metalloprotease Rip -
OO115_RS13905 (OO115_13905) 2950241..2951482 - 1242 WP_003414613.1 1-deoxy-D-xylulose-5-phosphate reductoisomerase -
OO115_RS13910 (OO115_13910) 2951609..2951866 + 258 WP_003414620.1 ribbon-helix-helix domain-containing protein Antitoxin
OO115_RS13915 (OO115_13915) 2951853..2952296 + 444 WP_003414624.1 type II toxin-antitoxin system VapC family toxin Toxin
OO115_RS13920 (OO115_13920) 2952376..2953038 + 663 WP_003414630.1 cell surface glycolipoprotein Mpt83 -
OO115_RS13925 (OO115_13925) 2953134..2953325 + 192 WP_003414632.1 type II toxin-antitoxin system prevent-host-death family antitoxin -
OO115_RS13930 (OO115_13930) 2953657..2955405 + 1749 WP_003912869.1 cytochrome c biogenesis protein DipZ -
OO115_RS13935 (OO115_13935) 2955501..2956082 + 582 WP_003414644.1 fasciclin domain-containing protein -
OO115_RS13940 (OO115_13940) 2956182..2956448 + 267 WP_015456449.1 DUF2631 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain toxin

(1-142)

Antitoxin

Ribbon-helix-helix protein, CopG

(2-38)


Sequences

Toxin        


Download         Length: 148 a.a.        Molecular weight: 16595.72 Da        Isoelectric Point: 6.4890

>T264172 WP_003414624.1 NZ_CP110674:2951853-2952296 [Mycobacterium tuberculosis]
MLCVDVNVLVYAHRADLREHADYRGLLERLANDDEPLGLPDSVLAGFIRVVTNRRVFTEPTSPQDAWQAVDALLAAPAAM
RLRPGERHWMAFRQLASDVDANGNDIADAHLAAYALENNATWLSADRGFARFRRLRWRHPLDGQTHL

Download         Length: 444 bp

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9013.22 Da        Isoelectric Point: 10.8344

>AT264172 WP_003414620.1 NZ_CP110674:2951609-2951866 [Mycobacterium tuberculosis]
VRTTIRIDDELYREVKAKAARSGRTVAAVLEDAVRRGLNPPKPQAAGRYRVQPSGKGGLRPGVDLSSNAALAEAMNDGVS
VDAVR

Download         Length: 258 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7VWO

Antitoxin

Source ID Structure
AlphaFold DB G0TFH0

References