Detailed information of TA system TA026417

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/PIN-AbrB
• Location: 2126648..2127254
• Replicon: chromosome
• Accession: NC_017275
• Organism: Sulfolobus islandicus HVE10/4

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: M9UBU6
• Locus tag: SIH_RS11645
• Protein ID: WP_014513042.1
• Coordinates: 2126850..2127254 (+)
• Length: 135 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: M9UBQ9
• Locus tag: SIH_RS11640
• Protein ID: WP_009989091.1
• Coordinates: 2126648..2126869 (+)
• Length: 74 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
SIH_RS11615 (SiH_2222)	2122471..2123088	+	618	WP_012712231.1	hypothetical protein	-
SIH_RS11620 (SiH_2223)	2123085..2123471	+	387	WP_014513039.1	hypothetical protein	-
SIH_RS11625 (SiH_2224)	2123468..2124133	-	666	WP_014513040.1	helix-turn-helix domain-containing protein	-
SIH_RS11630 (SiH_2225)	2124252..2125523	-	1272	WP_014513041.1	MFS transporter	-
SIH_RS11635	2125578..2125889	-	312	WP_258164983.1	DMT family transporter	-
SIH_RS14890	2125924..2126079	-	156	WP_157651795.1	hypothetical protein	-
SIH_RS11640 (SiH_2226)	2126648..2126869	+	222	WP_009989091.1	AbrB/MazE/SpoVT family DNA-binding domain-containing protein	Antitoxin
SIH_RS11645 (SiH_2227)	2126850..2127254	+	405	WP_014513042.1	PIN domain-containing protein	Toxin
SIH_RS11650	2127450..2127758	-	309	WP_258164966.1	transposase	-
SIH_RS14895	2127779..2127886	+	108	Protein_2333	IS110 family transposase	-
SIH_RS11655 (SiH_2228)	2128418..2129197	-	780	WP_014513043.1	DMT family transporter	-
SIH_RS11660 (SiH_2229)	2130032..2130214	+	183	WP_009990866.1	hypothetical protein	-
SIH_RS11665 (SiH_2230)	2130362..2131123	+	762	WP_014513044.1	ZIP family metal transporter	-
SIH_RS11670 (SiH_2231)	2131161..2132069	+	909	WP_014513045.1	dihydrodipicolinate synthase family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (5-126)

Antitoxin

• SpoVT-AbrB domain (4-48)

Sequences

Toxin

Protein

• Length: 135 a.a.
• Molecular weight: 15441.05 Da
• Isoelectric Point: 5.2947

>T26417 WP_014513042.1 NC_017275:2126850-2127254 [Sulfolobus islandicus HVE10/4]
VEKAIVDTNVIIYDYVEDSEYHKRAEELLDSLDRWVIPVIVVHEIMWFLKGMKLEDKVDDVLAYIRSEKAEVVCDCTDNV
TDAIGVLKKEKLPLVSYKDMVILSHAIREKLPLATFDRKLSKIAKKYSVSLLQS

Nucleotide

• Length: 405 bp

>T26417 NC_017275:2126850-2127254 [Sulfolobus islandicus HVE10/4]
GTGGAGAAGGCAATAGTTGACACTAACGTGATAATTTACGACTACGTTGAAGACTCCGAATATCATAAGAGGGCGGAAGA
GCTTCTCGATAGTTTGGATAGGTGGGTAATTCCCGTGATTGTAGTTCATGAGATCATGTGGTTCTTAAAGGGCATGAAAC
TTGAAGACAAGGTAGATGACGTTTTGGCTTATATTAGAAGTGAGAAAGCTGAGGTTGTCTGCGATTGTACAGATAACGTC
ACTGACGCTATAGGAGTGCTGAAGAAGGAAAAGCTTCCCTTGGTCAGCTACAAAGATATGGTAATACTTTCTCACGCAAT
TAGAGAAAAATTGCCTTTAGCCACTTTTGATAGGAAACTCTCAAAGATAGCAAAGAAGTACTCCGTAAGTTTACTACAGT
CGTAA

Antitoxin

Protein

• Length: 74 a.a.
• Molecular weight: 8267.50 Da
• Isoelectric Point: 9.6908

>AT26417 WP_009989091.1 NC_017275:2126648-2126869 [Sulfolobus islandicus HVE10/4]
MERVKVTRNYQITIPASARSKINIKEGDILEVYLNGDEIVLRKVKTERPRIRLGSKLSLGDIEEAIERGEGNS

Nucleotide

• Length: 222 bp

>AT26417 NC_017275:2126648-2126869 [Sulfolobus islandicus HVE10/4]
ATGGAGAGGGTAAAGGTTACGAGAAATTACCAGATAACTATTCCGGCCTCGGCTAGGAGTAAGATTAATATAAAAGAAGG
AGATATACTTGAGGTTTACTTGAACGGTGACGAGATAGTACTTCGGAAGGTTAAGACTGAGAGGCCGAGGATAAGGCTAG
GCAGTAAACTCTCACTGGGAGATATTGAGGAGGCAATAGAGCGTGGAGAAGGCAATAGTTGA

Structures

Toxin

• AlphaFold DB: M9UBU6

Antitoxin

• AlphaFold DB: M9UBQ9