Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 2884893..2885463 Replicon chromosome
Accession NZ_CP110674
Organism Mycobacterium tuberculosis strain BLR-31d

Toxin (Protein)


Gene name mazF Uniprot ID P71650
Locus tag OO115_RS13560 Protein ID WP_003414166.1
Coordinates 2884893..2885249 (-) Length 119 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID P0CL61
Locus tag OO115_RS13565 Protein ID WP_003901465.1
Coordinates 2885233..2885463 (-) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OO115_RS13540 (OO115_13540) 2880345..2882033 - 1689 WP_003414155.1 alpha/beta hydrolase family protein -
OO115_RS13545 (OO115_13545) 2882037..2882363 - 327 WP_003414157.1 hypothetical protein -
OO115_RS13550 (OO115_13550) 2882536..2883123 + 588 WP_003914429.1 DUF3558 family protein -
OO115_RS13555 (OO115_13555) 2883142..2884791 + 1650 Protein_2681 CocE/NonD family hydrolase -
OO115_RS13560 (OO115_13560) 2884893..2885249 - 357 WP_003414166.1 type II toxin-antitoxin system toxin endoribonuclease MazF9 Toxin
OO115_RS13565 (OO115_13565) 2885233..2885463 - 231 WP_003901465.1 type II toxin-antitoxin system antitoxin MazE9 Antitoxin
OO115_RS13570 (OO115_13570) 2885506..2886549 - 1044 WP_003414172.1 DUF2293 domain-containing protein -
OO115_RS13575 (OO115_13575) 2886548..2887015 + 468 WP_003414177.1 DUF1778 domain-containing protein -
OO115_RS13580 (OO115_13580) 2887191..2887445 - 255 WP_003917684.1 hypothetical protein -
OO115_RS13585 (OO115_13585) 2887593..2887997 + 405 WP_003414181.1 hypothetical protein -
OO115_RS13590 (OO115_13590) 2887994..2888185 + 192 WP_003414184.1 hypothetical protein -
OO115_RS13595 (OO115_13595) 2888402..2888662 + 261 Protein_2689 transposase -
OO115_RS13600 (OO115_13600) 2889772..2890029 + 258 WP_003899489.1 hypothetical protein -
OO115_RS13605 (OO115_13605) 2890134..2890445 + 312 WP_003414190.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(3-113)

Antitoxin

Ribbon-helix-helix protein, CopG

(3-29)


Sequences

Toxin        


Download         Length: 119 a.a.        Molecular weight: 12858.73 Da        Isoelectric Point: 9.1962

>T264168 WP_003414166.1 NZ_CP110674:c2885249-2884893 [Mycobacterium tuberculosis]
VMRRGEIWQVDLDPARGSEANNQRPAVVVSNDRANATATRLGRGVITVVPVTSNIAKVYPFQVLLSATTTGLQVDCKAQA
EQIRSIATERLLRPIGRVSAAELAQLDEALKLHLDLWS

Download         Length: 357 bp

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8231.01 Da        Isoelectric Point: 4.1809

>AT264168 WP_003901465.1 NZ_CP110674:c2885463-2885233 [Mycobacterium tuberculosis]
VKLSVSLSDDDVAILDAYVKRAGLPSRSAGLQHAIRVLRYPTLEDDYANAWQEWSAAGDTDAWEQTVGDGVGDAPR

Download         Length: 231 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6L2A
PDB 5HJZ
PDB 6KYT
PDB 6L29
PDB 7DU5
PDB 6KYS

Antitoxin

Source ID Structure
PDB 7DU5
PDB 6KYT
AlphaFold DB A0A7U4FBW3

References