264165

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 2704546..2705260 Replicon chromosome
Accession NZ_CP110674
Organism Mycobacterium tuberculosis strain BLR-31d

Toxin (Protein)


Gene name vapC Uniprot ID G0TQK0
Locus tag OO115_RS12500 Protein ID WP_003413460.1
Coordinates 2704820..2705260 (+) Length 147 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID P9WJ20
Locus tag OO115_RS12495 Protein ID WP_003413456.1
Coordinates 2704546..2704833 (+) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OO115_RS12460 (OO115_12460) 2699968..2700213 + 246 WP_003413429.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein -
OO115_RS12465 (OO115_12465) 2700210..2700614 + 405 WP_003413432.1 type II toxin-antitoxin system VapC family toxin -
OO115_RS12470 (OO115_12470) 2700831..2701451 + 621 WP_003413441.1 DUF4178 domain-containing protein -
OO115_RS12475 (OO115_12475) 2701462..2701956 + 495 WP_003413444.1 DUF2617 family protein -
OO115_RS12480 (OO115_12480) 2701953..2702384 + 432 WP_003899390.1 DUF4247 domain-containing protein -
OO115_RS12485 (OO115_12485) 2702409..2702867 + 459 WP_003413451.1 DUF350 domain-containing protein -
OO115_RS12490 (OO115_12490) 2702864..2704435 + 1572 WP_003899392.1 polyamine aminopropyltransferase -
OO115_RS12495 (OO115_12495) 2704546..2704833 + 288 WP_003413456.1 antitoxin VapB41 Antitoxin
OO115_RS12500 (OO115_12500) 2704820..2705260 + 441 WP_003413460.1 type II toxin-antitoxin system VapC family toxin Toxin
OO115_RS12505 (OO115_12505) 2705281..2706036 - 756 WP_003413464.1 YebC/PmpR family DNA-binding transcriptional regulator -
OO115_RS12510 (OO115_12510) 2706169..2706765 - 597 WP_003413465.1 pyridoxal 5'-phosphate synthase glutaminase subunit PdxT -
OO115_RS12515 (OO115_12515) 2706773..2707618 - 846 WP_003413466.1 acyl-CoA thioesterase II -
OO115_RS12520 (OO115_12520) 2707647..2708546 - 900 WP_003413468.1 pyridoxal 5'-phosphate synthase lyase subunit PdxS -
OO115_RS12525 (OO115_12525) 2708674..2709348 + 675 WP_003413471.1 pyridoxamine 5'-phosphate oxidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain toxin

(1-146)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 147 a.a.        Molecular weight: 16026.38 Da        Isoelectric Point: 6.8599

>T264165 WP_003413460.1 NZ_CP110674:2704820-2705260 [Mycobacterium tuberculosis]
MLLCDTNIWLALALSGHVHHRASRAWLDTINAPGVIHFCRATQQSLLRLLTNRTVLGAYGSPPLTNREAWAAYAAFLDDD
RIVLAGAEPDGLEAQWRAFAVRQSPAPKVWMDAYLAAFALTGGFELVTTDTAFTQYGGIELRLLAK

Download         Length: 441 bp

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10453.98 Da        Isoelectric Point: 7.2797

>AT264165 WP_003413456.1 NZ_CP110674:2704546-2704833 [Mycobacterium tuberculosis]
MKTTLDLPDELMRAIKVRAAQQGRKMKDVVTELLRSGLSQTHSGAPIPTPRRVQLPLVHCGGAATREQEMTPERVAAALL
DQEAQWWSGHDDAAL

Download         Length: 288 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0TQK0

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4BWB8

References