264164

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 2644204..2644841 Replicon chromosome
Accession NZ_CP110674
Organism Mycobacterium tuberculosis strain BLR-31d

Toxin (Protein)


Gene name vapC Uniprot ID P0DMV7
Locus tag OO115_RS12235 Protein ID WP_003413180.1
Coordinates 2644204..2644599 (-) Length 132 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID P9WJ44
Locus tag OO115_RS12240 Protein ID WP_003413183.1
Coordinates 2644596..2644841 (-) Length 82 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OO115_RS12195 (OO115_12195) 2639608..2640819 + 1212 WP_003900845.1 alpha/beta hydrolase family protein -
OO115_RS12200 (OO115_12200) 2640946..2641605 + 660 WP_003902296.1 LppA family lipoprotein -
OO115_RS12205 (OO115_12205) 2641602..2642264 + 663 WP_003905878.1 LppA family lipoprotein -
OO115_RS12210 (OO115_12210) 2642261..2642538 + 278 Protein_2416 type II toxin-antitoxin system VapB family antitoxin -
OO115_RS12215 (OO115_12215) 2642631..2643044 + 414 WP_003413164.1 PIN domain nuclease -
OO115_RS12220 (OO115_12220) 2643083..2643340 + 258 WP_003413167.1 CopG family transcriptional regulator -
OO115_RS12225 (OO115_12225) 2643337..2643714 + 378 WP_003413174.1 type II toxin-antitoxin system VapC family toxin -
OO115_RS12230 (OO115_12230) 2643730..2644104 - 375 WP_003413177.1 hypothetical protein -
OO115_RS12235 (OO115_12235) 2644204..2644599 - 396 WP_003413180.1 type II toxin-antitoxin system toxin 23S rRNA-specific endonuclease VapC20 Toxin
OO115_RS12240 (OO115_12240) 2644596..2644841 - 246 WP_003413183.1 type II toxin-antitoxin system antitoxin VapB20 Antitoxin
OO115_RS12245 (OO115_12245) 2645252..2645671 - 420 WP_003413190.1 A24 family peptidase -
OO115_RS12250 (OO115_12250) 2645683..2646492 - 810 WP_003413193.1 shikimate dehydrogenase -
OO115_RS12255 (OO115_12255) 2646489..2647742 - 1254 WP_003413196.1 endolytic transglycosylase MltG -
OO115_RS12260 (OO115_12260) 2647735..2648247 - 513 WP_003413197.1 Holliday junction resolvase RuvX -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Endonuclease VapC20-like

(1-129)

Antitoxin

Ribbon-helix-helix protein, CopG

(11-49)


Sequences

Toxin        


Download         Length: 132 a.a.        Molecular weight: 14619.53 Da        Isoelectric Point: 6.9794

>T264164 WP_003413180.1 NZ_CP110674:c2644599-2644204 [Mycobacterium tuberculosis]
MIFVDTSFWAALGNAGDARHGTAKRLWASKPPVVMTSNHVLGETWTLLNRRCGHRAAVAAAAIRLSTVVRVEHVTADLEE
QAWEWLVRHDEREYSFVDATSFAVMRKKGIQNAYAFDGDFSAAGFVEVRPE

Download         Length: 396 bp

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 9098.33 Da        Isoelectric Point: 5.6007

>AT264164 WP_003413183.1 NZ_CP110674:c2644841-2644596 [Mycobacterium tuberculosis]
MLVAYICHVKRLQIYIDEDVDRALAVEARRRRTSKAALIREYVAEHLRQPGPDPVDAFVGSFVGEADLSASVDDVVYGKH
E

Download         Length: 246 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 5WZ4
PDB 5WZF

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4BW31

References