264163

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1(toxin)
Location 2643083..2643714 Replicon chromosome
Accession NZ_CP110674
Organism Mycobacterium tuberculosis strain BLR-31d

Toxin (Protein)


Gene name vapC Uniprot ID G0TQ28
Locus tag OO115_RS12225 Protein ID WP_003413174.1
Coordinates 2643337..2643714 (+) Length 126 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID P95006
Locus tag OO115_RS12220 Protein ID WP_003413167.1
Coordinates 2643083..2643340 (+) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OO115_RS12190 (OO115_12190) 2638998..2639312 + 315 WP_009937839.1 hypothetical protein -
OO115_RS12195 (OO115_12195) 2639608..2640819 + 1212 WP_003900845.1 alpha/beta hydrolase family protein -
OO115_RS12200 (OO115_12200) 2640946..2641605 + 660 WP_003902296.1 LppA family lipoprotein -
OO115_RS12205 (OO115_12205) 2641602..2642264 + 663 WP_003905878.1 LppA family lipoprotein -
OO115_RS12210 (OO115_12210) 2642261..2642538 + 278 Protein_2416 type II toxin-antitoxin system VapB family antitoxin -
OO115_RS12215 (OO115_12215) 2642631..2643044 + 414 WP_003413164.1 PIN domain nuclease -
OO115_RS12220 (OO115_12220) 2643083..2643340 + 258 WP_003413167.1 CopG family transcriptional regulator Antitoxin
OO115_RS12225 (OO115_12225) 2643337..2643714 + 378 WP_003413174.1 type II toxin-antitoxin system VapC family toxin Toxin
OO115_RS12230 (OO115_12230) 2643730..2644104 - 375 WP_003413177.1 hypothetical protein -
OO115_RS12235 (OO115_12235) 2644204..2644599 - 396 WP_003413180.1 type II toxin-antitoxin system toxin 23S rRNA-specific endonuclease VapC20 -
OO115_RS12240 (OO115_12240) 2644596..2644841 - 246 WP_003413183.1 type II toxin-antitoxin system antitoxin VapB20 -
OO115_RS12245 (OO115_12245) 2645252..2645671 - 420 WP_003413190.1 A24 family peptidase -
OO115_RS12250 (OO115_12250) 2645683..2646492 - 810 WP_003413193.1 shikimate dehydrogenase -
OO115_RS12255 (OO115_12255) 2646489..2647742 - 1254 WP_003413196.1 endolytic transglycosylase MltG -
OO115_RS12260 (OO115_12260) 2647735..2648247 - 513 WP_003413197.1 Holliday junction resolvase RuvX -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(3-111)

Antitoxin

Ribbon-helix-helix protein, CopG

(2-38)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 13728.72 Da        Isoelectric Point: 4.4687

>T264163 WP_003413174.1 NZ_CP110674:2643337-2643714 [Mycobacterium tuberculosis]
VKLIDTTIAVDHLRGEPAAAVLLAELINNGEEIAASELVRFELLAGVRESELAALEAFFSAVVWTLVTEDIARIGGRLAR
RYRSSHRGIDDVDYLIAATAIVVDADLLTTNVRHFPMFPDLQPPY

Download         Length: 378 bp

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9453.63 Da        Isoelectric Point: 10.6555

>AT264163 WP_003413167.1 NZ_CP110674:2643083-2643340 [Mycobacterium tuberculosis]
MRTQVTLGKEELELLDRAAKASGASRSELIRRAIHRAYGTGSKQERLAALDHSRGSWRGRDFTGTEYVDAIRGDLNERLA
RLGLA

Download         Length: 258 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0TQ28

Antitoxin

Source ID Structure
AlphaFold DB A0A829C9W5

References