264161

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 2628745..2629385 Replicon chromosome
Accession NZ_CP110674
Organism Mycobacterium tuberculosis strain BLR-31d

Toxin (Protein)


Gene name vapC Uniprot ID G0TQ08
Locus tag OO115_RS12130 Protein ID WP_003412970.1
Coordinates 2628745..2629164 (-) Length 140 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID G0TQ09
Locus tag OO115_RS12135 Protein ID WP_003412975.1
Coordinates 2629161..2629385 (-) Length 75 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OO115_RS12100 (OO115_12100) 2624335..2625057 - 723 WP_003412957.1 DUF1906 domain-containing protein -
OO115_RS12105 (OO115_12105) 2625574..2625796 + 223 Protein_2395 type II toxin-antitoxin system VapB family antitoxin -
OO115_RS12110 (OO115_12110) 2625793..2626194 + 402 WP_003412963.1 PIN domain-containing protein -
OO115_RS12115 (OO115_12115) 2626229..2627149 - 921 WP_003412965.1 restriction endonuclease -
OO115_RS12120 (OO115_12120) 2627490..2627735 - 246 WP_071854223.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein -
OO115_RS12125 (OO115_12125) 2627794..2628744 + 951 WP_003911916.1 ERCC4 domain-containing protein -
OO115_RS12130 (OO115_12130) 2628745..2629164 - 420 WP_003412970.1 type II toxin-antitoxin system VapC family toxin Toxin
OO115_RS12135 (OO115_12135) 2629161..2629385 - 225 WP_003412975.1 antitoxin VapB39 Antitoxin
OO115_RS12140 (OO115_12140) 2629416..2632259 - 2844 WP_003899363.1 aminotransferase class I/II-fold pyridoxal phosphate-dependent enzyme -
OO115_RS12145 (OO115_12145) 2632331..2632732 - 402 WP_003412981.1 hypothetical protein -
OO115_RS12150 (OO115_12150) 2632732..2633202 - 471 WP_003899364.1 transcription antitermination factor NusB -
OO115_RS12155 (OO115_12155) 2633205..2633768 - 564 WP_003412989.1 elongation factor P -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-128)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 140 a.a.        Molecular weight: 14732.70 Da        Isoelectric Point: 6.7519

>T264161 WP_003412970.1 NZ_CP110674:c2629164-2628745 [Mycobacterium tuberculosis]
VTALLDVNVLIALGWPNHVHHAAAQRWFTQFSSNGWATTPITEAGYVRISSNRSVMQVSTTPAIAIAQLAAMTSLAGHTF
WPDDVPLIVGSAGDRDAVSNHRRVTDCHLIALAARYGGRLVTFDAALADSASAGLVEVL

Download         Length: 420 bp

Antitoxin


Download         Length: 75 a.a.        Molecular weight: 7993.94 Da        Isoelectric Point: 4.0057

>AT264161 WP_003412975.1 NZ_CP110674:c2629385-2629161 [Mycobacterium tuberculosis]
MRTTLQIDDDVLEDARSIARSEGKSVGAVISELARRSLRPVGIVEVDGFPVFDVPPDAPTVTSEDVVRALEDDV

Download         Length: 225 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0TQ08

Antitoxin

Source ID Structure
AlphaFold DB G0TQ09

References