Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | vapBC/PIN(toxin) |
Location | 2582569..2583221 | Replicon | chromosome |
Accession | NZ_CP110674 | ||
Organism | Mycobacterium tuberculosis strain BLR-31d |
Toxin (Protein)
Gene name | vapC | Uniprot ID | A0A5R1ZCY8 |
Locus tag | OO115_RS11935 | Protein ID | WP_003905869.1 |
Coordinates | 2582796..2583221 (+) | Length | 142 a.a. |
Antitoxin (Protein)
Gene name | vapB | Uniprot ID | P9WJ24 |
Locus tag | OO115_RS11930 | Protein ID | WP_003412749.1 |
Coordinates | 2582569..2582790 (+) | Length | 74 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
OO115_RS11915 (OO115_11915) | 2580809..2581015 | - | 207 | WP_003899347.1 | hypothetical protein | - |
OO115_RS11920 (OO115_11920) | 2581151..2581774 | + | 624 | WP_003900858.1 | TIGR00725 family protein | - |
OO115_RS11925 (OO115_11925) | 2581764..2582516 | + | 753 | WP_003901416.1 | hypothetical protein | - |
OO115_RS11930 (OO115_11930) | 2582569..2582790 | + | 222 | WP_003412749.1 | antitoxin | Antitoxin |
OO115_RS11935 (OO115_11935) | 2582796..2583221 | + | 426 | WP_003905869.1 | type II toxin-antitoxin system VapC family toxin | Toxin |
OO115_RS11940 (OO115_11940) | 2583244..2584425 | - | 1182 | WP_003905870.1 | dihydrolipoamide acetyltransferase family protein | - |
OO115_RS11945 (OO115_11945) | 2584422..2585468 | - | 1047 | WP_003412757.1 | 3-methyl-2-oxobutanoate dehydrogenase subunit beta | - |
OO115_RS11950 (OO115_11950) | 2585479..2586582 | - | 1104 | WP_003412761.1 | pyruvate dehydrogenase (acetyl-transferring) E1 component subunit alpha | - |
OO115_RS11955 (OO115_11955) | 2586841..2587662 | - | 822 | WP_003412766.1 | citrate (pro-3S)-lyase subunit beta | - |
OO115_RS11960 (OO115_11960) | 2587659..2588216 | - | 558 | WP_003412768.1 | MaoC family dehydratase | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 142 a.a. Molecular weight: 15364.84 Da Isoelectric Point: 9.2386
>T264160 WP_003905869.1 NZ_CP110674:2582796-2583221 [Mycobacterium tuberculosis]
VALLDVNALVALAWDSHIHHARIREWFTANATLGWATCPLTEAGFVRASTNPKVLPSAIGIADARRVLVALRAVGGHRFL
ADDVSLVDDDVPLIVGYRQVTDAHLLTLARRRGVRLVTFDAGVFTLAQQRPKTPVELLTIL
VALLDVNALVALAWDSHIHHARIREWFTANATLGWATCPLTEAGFVRASTNPKVLPSAIGIADARRVLVALRAVGGHRFL
ADDVSLVDDDVPLIVGYRQVTDAHLLTLARRRGVRLVTFDAGVFTLAQQRPKTPVELLTIL
Download Length: 426 bp
Antitoxin
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A5R1ZCY8 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A7U4BW03 |