Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | vapBC/PIN(toxin) |
| Location | 996048..996654 | Replicon | chromosome |
| Accession | NC_017275 | ||
| Organism | Sulfolobus islandicus HVE10/4 | ||
Toxin (Protein)
| Gene name | vapC | Uniprot ID | M9U4G3 |
| Locus tag | SIH_RS05280 | Protein ID | WP_012710548.1 |
| Coordinates | 996292..996654 (+) | Length | 121 a.a. |
Antitoxin (Protein)
| Gene name | vapB | Uniprot ID | M9UCL5 |
| Locus tag | SIH_RS05275 | Protein ID | WP_012718013.1 |
| Coordinates | 996048..996269 (+) | Length | 74 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| SIH_RS05235 (SiH_0980) | 991213..991629 | + | 417 | WP_014512464.1 | hypothetical protein | - |
| SIH_RS05240 (SiH_0981) | 991610..992212 | + | 603 | WP_014512465.1 | urease accessory UreF family protein | - |
| SIH_RS05245 (SiH_0982) | 992209..992814 | + | 606 | WP_014512466.1 | urease accessory protein UreG | - |
| SIH_RS05250 (SiH_0983) | 992826..993407 | + | 582 | WP_237702661.1 | urease accessory protein UreD | - |
| SIH_RS15525 (SiH_0984) | 993454..993588 | + | 135 | WP_014512468.1 | hypothetical protein | - |
| SIH_RS15190 | 994660..994824 | + | 165 | WP_193385925.1 | hypothetical protein | - |
| SIH_RS05270 (SiH_0986) | 994811..995905 | + | 1095 | WP_014512470.1 | hypothetical protein | - |
| SIH_RS05275 (SiH_0987) | 996048..996269 | + | 222 | WP_012718013.1 | hypothetical protein | Antitoxin |
| SIH_RS05280 (SiH_0988) | 996292..996654 | + | 363 | WP_012710548.1 | type II toxin-antitoxin system VapC family toxin | Toxin |
| SIH_RS05285 (SiH_0989) | 996782..997987 | - | 1206 | WP_052891907.1 | RNA-guided endonuclease TnpB family protein | - |
| SIH_RS05290 (SiH_0990) | 998432..999985 | - | 1554 | WP_014512472.1 | aldehyde dehydrogenase family protein | - |
| SIH_RS05295 (SiH_0991) | 1000077..1000670 | + | 594 | WP_012718017.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | flank | IS/Tn | - | - | 996782..998035 | 1253 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 121 a.a. Molecular weight: 13870.21 Da Isoelectric Point: 9.2430
>T26416 WP_012710548.1 NC_017275:996292-996654 [Sulfolobus islandicus HVE10/4]
VTKEKGWNRITELLKDSETLDLALVEVSNVIWKKVVLTNEITPQDANKAIMIIKEYLPQLLTVNKSVKLLERAIDISIRE
KLTIYDSLYIALAESKRSKLLTSDKKQYEVARKYVDSELF
VTKEKGWNRITELLKDSETLDLALVEVSNVIWKKVVLTNEITPQDANKAIMIIKEYLPQLLTVNKSVKLLERAIDISIRE
KLTIYDSLYIALAESKRSKLLTSDKKQYEVARKYVDSELF
Download Length: 363 bp
>T26416 NC_017275:996292-996654 [Sulfolobus islandicus HVE10/4]
GTGACTAAGGAGAAGGGATGGAATAGAATTACGGAGTTACTAAAGGATAGTGAAACTCTAGATCTGGCGCTAGTAGAAGT
TTCCAATGTTATTTGGAAGAAAGTGGTGTTAACAAACGAGATTACTCCACAGGATGCCAATAAGGCGATTATGATTATTA
AGGAATATCTACCTCAATTGCTGACTGTAAATAAAAGCGTTAAACTCTTGGAAAGAGCTATAGATATCTCTATAAGGGAA
AAACTGACTATATACGACTCGCTATATATTGCCTTAGCGGAAAGCAAGAGAAGTAAATTATTAACCAGCGATAAAAAGCA
ATATGAGGTTGCAAGAAAATACGTGGACTCGGAATTATTTTAG
GTGACTAAGGAGAAGGGATGGAATAGAATTACGGAGTTACTAAAGGATAGTGAAACTCTAGATCTGGCGCTAGTAGAAGT
TTCCAATGTTATTTGGAAGAAAGTGGTGTTAACAAACGAGATTACTCCACAGGATGCCAATAAGGCGATTATGATTATTA
AGGAATATCTACCTCAATTGCTGACTGTAAATAAAAGCGTTAAACTCTTGGAAAGAGCTATAGATATCTCTATAAGGGAA
AAACTGACTATATACGACTCGCTATATATTGCCTTAGCGGAAAGCAAGAGAAGTAAATTATTAACCAGCGATAAAAAGCA
ATATGAGGTTGCAAGAAAATACGTGGACTCGGAATTATTTTAG
Antitoxin
Download Length: 74 a.a. Molecular weight: 8952.22 Da Isoelectric Point: 4.6475
>AT26416 WP_012718013.1 NC_017275:996048-996269 [Sulfolobus islandicus HVE10/4]
MKMVYSLRIDKELREEMEKYDIKWNEEIEGFIRKRLEELKKEEILKRINEILSTMPETNSSSAEMVREDRDNN
MKMVYSLRIDKELREEMEKYDIKWNEEIEGFIRKRLEELKKEEILKRINEILSTMPETNSSSAEMVREDRDNN
Download Length: 222 bp
>AT26416 NC_017275:996048-996269 [Sulfolobus islandicus HVE10/4]
ATGAAAATGGTATACAGTTTAAGGATAGATAAAGAATTACGTGAGGAGATGGAAAAGTACGACATAAAGTGGAATGAAGA
GATAGAGGGTTTCATAAGGAAAAGGCTTGAGGAATTGAAAAAAGAGGAGATTCTAAAGAGGATTAATGAGATCCTTTCAA
CCATGCCGGAAACTAATTCAAGTAGTGCGGAAATGGTGAGGGAAGATAGGGATAATAATTGA
ATGAAAATGGTATACAGTTTAAGGATAGATAAAGAATTACGTGAGGAGATGGAAAAGTACGACATAAAGTGGAATGAAGA
GATAGAGGGTTTCATAAGGAAAAGGCTTGAGGAATTGAAAAAAGAGGAGATTCTAAAGAGGATTAATGAGATCCTTTCAA
CCATGCCGGAAACTAATTCAAGTAGTGCGGAAATGGTGAGGGAAGATAGGGATAATAATTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|