264158

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 2140364..2141059 Replicon chromosome
Accession NZ_CP110674
Organism Mycobacterium tuberculosis strain BLR-31d

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag OO115_RS09815 Protein ID WP_003905754.1
Coordinates 2140364..2140798 (-) Length 145 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID G0TMN0
Locus tag OO115_RS09820 Protein ID WP_003410814.1
Coordinates 2140805..2141059 (-) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OO115_RS09805 (OO115_09805) 2136518..2139559 + 3042 WP_003899171.1 DEAD/DEAH box helicase -
OO115_RS09810 (OO115_09810) 2139552..2140385 + 834 WP_003899172.1 SWIM zinc finger family protein -
OO115_RS09815 (OO115_09815) 2140364..2140798 - 435 WP_003905754.1 type II toxin-antitoxin system VapC family toxin Toxin
OO115_RS09820 (OO115_09820) 2140805..2141059 - 255 WP_003410814.1 antitoxin Antitoxin
OO115_RS09825 (OO115_09825) 2141075..2141332 - 258 WP_003410816.1 hypothetical protein -
OO115_RS09830 (OO115_09830) 2141866..2143127 + 1262 WP_087902221.1 IS3-like element IS987 family transposase -
OO115_RS09840 (OO115_09840) 2144995..2145291 + 297 WP_003410820.1 PE family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 2133009..2144790 11781


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain toxin

(1-142)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 145 a.a.        Molecular weight: 15632.05 Da        Isoelectric Point: 7.4681

>T264158 WP_003905754.1 NZ_CP110674:c2140798-2140364 [Mycobacterium tuberculosis]
MKIVDANVLLYAVNTASEHHKPSLRWLDGALSGADRVGFAWVPLLAFVRLATKVGLFPRPLPREAAITQVADWLAAPSAV
LVNPTVRHADILARMLTYVGTGANLVNDAHLAALAVEHRASIVSYDSDFGRFEGVRWDQPPALL

Download         Length: 435 bp

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9417.57 Da        Isoelectric Point: 8.9912

>AT264158 WP_003410814.1 NZ_CP110674:c2141059-2140805 [Mycobacterium tuberculosis]
MRTTVTLDDDVEQLVRRRMAERQVSFKKALNDAIRDGASGRPAPSHFSTRTADLGVPAVNLDRALQLAADLEDEELVRRQ
RRGS

Download         Length: 255 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB G0TMN0

References