264157

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/PemK(toxin)
Location 2097030..2097666 Replicon chromosome
Accession NZ_CP110674
Organism Mycobacterium tuberculosis strain BLR-31d

Toxin (Protein)


Gene name mazF Uniprot ID P0CL62
Locus tag OO115_RS09620 Protein ID WP_003410654.1
Coordinates 2097256..2097666 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID P9WJ84
Locus tag OO115_RS09615 Protein ID WP_003410651.1
Coordinates 2097030..2097263 (+) Length 78 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OO115_RS09600 (OO115_09600) 2092478..2092879 + 402 WP_009937711.1 metal ABC transporter permease -
OO115_RS09605 (OO115_09605) 2092880..2093284 - 405 WP_003410645.1 PPOX class F420-dependent oxidoreductase -
OO115_RS09610 (OO115_09610) 2093368..2096952 - 3585 WP_003910889.1 cobaltochelatase subunit CobN -
OO115_RS09615 (OO115_09615) 2097030..2097263 + 234 WP_003410651.1 type II toxin-antitoxin system antitoxin MazE7 Antitoxin
OO115_RS09620 (OO115_09620) 2097256..2097666 + 411 WP_003410654.1 type II toxin-antitoxin system toxin endoribonuclease MazF7 Toxin
OO115_RS09625 (OO115_09625) 2097650..2098741 + 1092 WP_003900454.1 precorrin-3B synthase -
OO115_RS09630 (OO115_09630) 2098751..2099377 + 627 WP_003410658.1 precorrin-8X methylmutase -
OO115_RS09635 (OO115_09635) 2099374..2100900 + 1527 WP_003410659.1 precorrin-2 C(20)-methyltransferase -
OO115_RS09640 (OO115_09640) 2100846..2102069 - 1224 WP_003901321.1 class I SAM-dependent methyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(5-110)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 14235.42 Da        Isoelectric Point: 10.6228

>T264157 WP_003410654.1 NZ_CP110674:2097256-2097666 [Mycobacterium tuberculosis]
MAEPRRGDLWLVSLGAARAGEPGKHRPAVVVSVDELLTGIDDELVVVVPVSSSRSRTPLRPPVAPSEGVAADSVAVCRGV
RAVARARLVERLGALKPATMRAIENALTLILGLPTGPERGEAATHSPVRWTGGRDP

Download         Length: 411 bp

Antitoxin


Download         Length: 78 a.a.        Molecular weight: 8450.25 Da        Isoelectric Point: 4.7954

>AT264157 WP_003410651.1 NZ_CP110674:2097030-2097263 [Mycobacterium tuberculosis]
MSTSTTIRVSTQTRDRLAAQARERGISMSALLTELAAQAERQAIFRAEREASHAETTTQAVRDEDREWEGTVGDGLG

Download         Length: 234 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7DU4
PDB 5WYG
PDB 6A6X

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4BV50

References