264153

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mbcAT/RES-TIGR02293
Location 2002583..2003481 Replicon chromosome
Accession NZ_CP110674
Organism Mycobacterium tuberculosis strain BLR-31d

Toxin (Protein)


Gene name mbcT Uniprot ID P64908
Locus tag OO115_RS09195 Protein ID WP_003410001.1
Coordinates 2002583..2003143 (-) Length 187 a.a.

Antitoxin (Protein)


Gene name mbcA Uniprot ID P64910
Locus tag OO115_RS09200 Protein ID WP_003410003.1
Coordinates 2003140..2003481 (-) Length 114 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OO115_RS09165 (OO115_09165) 1997752..1998405 - 654 WP_003409976.1 cutinase Cfp21 -
OO115_RS09170 (OO115_09170) 1998520..1998750 + 231 WP_003409980.1 DUF167 domain-containing protein -
OO115_RS09175 (OO115_09175) 1998835..1999746 - 912 WP_003409986.1 ArgP/LysG family DNA-binding transcriptional regulator -
OO115_RS09180 (OO115_09180) 1999855..2000454 + 600 WP_003910883.1 L-lysine exporter -
OO115_RS09185 (OO115_09185) 2000870..2001298 + 429 WP_003409992.1 cellulose-binding protein -
OO115_RS09190 (OO115_09190) 2001524..2002063 + 540 WP_003900446.1 23S rRNA (adenine(2058)-N(6))-methyltransferase Erm(37) -
OO115_RS09195 (OO115_09195) 2002583..2003143 - 561 WP_003410001.1 RES family NAD+ phosphorylase Toxin
OO115_RS09200 (OO115_09200) 2003140..2003481 - 342 WP_003410003.1 DUF2384 domain-containing protein Antitoxin
OO115_RS09205 (OO115_09205) 2003567..2003824 + 258 WP_003410006.1 hypothetical protein -
OO115_RS09210 (OO115_09210) 2003725..2004060 - 336 WP_003410009.1 dehydrogenase -
OO115_RS09215 (OO115_09215) 2004149..2004493 - 345 WP_003410010.1 type II toxin-antitoxin system toxin endoribonuclease MazF6 -
OO115_RS09220 (OO115_09220) 2004487..2004735 - 249 WP_003410014.1 ribbon-helix-helix protein, CopG family -
OO115_RS09225 (OO115_09225) 2004835..2007150 - 2316 WP_003899120.1 cation transporter ATPase CptG -
OO115_RS09230 (OO115_09230) 2007147..2007419 - 273 WP_003410017.1 DUF1490 family protein -
OO115_RS09235 (OO115_09235) 2007472..2007828 - 357 WP_003410018.1 Cd(II)/Pb(II)-sensing metalloregulatory transcriptional regulator CmtR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

RES domain

(25-148)

Antitoxin

Antitoxin Xre/MbcA/ParS-like, toxin-binding domain

(69-110)


Sequences

Toxin        


Download         Length: 187 a.a.        Molecular weight: 20248.70 Da        Isoelectric Point: 4.5091

>T264153 WP_003410001.1 NZ_CP110674:c2003143-2002583 [Mycobacterium tuberculosis]
VSDALDEGLVQRIDARGTIEWSETCYRYTGAHRDALSGEGARRFGGRWNPPLLFPAIYLADSAQACMVEVERAAQAASTT
AEKMLEAAYRLHTIDVTDLAVLDLTTPQAREAVGLENDDIYGDDWSGCQAVGHAAWFLHMQGVLVPAAGGVGLVVTAYEQ
RTRPGQLQLRQSVDLTPALYQELRAT

Download         Length: 561 bp

Antitoxin


Download         Length: 114 a.a.        Molecular weight: 12488.33 Da        Isoelectric Point: 4.8359

>AT264153 WP_003410003.1 NZ_CP110674:c2003481-2003140 [Mycobacterium tuberculosis]
MGVNVLASTVSGAIERLGLTYEEVGDIVDASPRSVARWTAGQVVPQRLNKQRLIELAYVADALAEVLPRDQANVWMFSPN
RLLEHRKPADLVRDGEYQRVLALIDAMAEGVFV

Download         Length: 342 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6FKG

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4FAE4

References