26415

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN-CcdA
Location 702420..703026 Replicon chromosome
Accession NC_017275
Organism Sulfolobus islandicus HVE10/4

Toxin (Protein)


Gene name vapC Uniprot ID F0NNP3
Locus tag SIH_RS03790 Protein ID WP_014512246.1
Coordinates 702420..702812 (-) Length 131 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID F0NNP4
Locus tag SIH_RS03795 Protein ID WP_014512247.1
Coordinates 702802..703026 (-) Length 75 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SIH_RS03770 (SiH_0718) 697890..698864 + 975 WP_014512242.1 glycosyltransferase family A protein -
SIH_RS03775 (SiH_0719) 698854..700185 - 1332 WP_014512243.1 APC family permease -
SIH_RS03780 (SiH_0720) 700292..700867 - 576 WP_014512244.1 XdhC family protein -
SIH_RS03785 (SiH_0721) 701618..702094 - 477 Protein_759 cytochrome b558/566 subunit B -
SIH_RS03790 (SiH_0722) 702420..702812 - 393 WP_014512246.1 type II toxin-antitoxin system VapC family toxin Toxin
SIH_RS03795 (SiH_0723) 702802..703026 - 225 WP_014512247.1 type II toxin-antitoxin system CcdA family antitoxin Antitoxin
SIH_RS03800 703142..703845 - 704 Protein_762 helix-turn-helix domain-containing protein -
SIH_RS03805 (SiH_0725) 704055..706322 - 2268 WP_014512248.1 xanthine dehydrogenase family protein molybdopterin-binding subunit -
SIH_RS03810 (SiH_0726) 706325..707089 - 765 WP_014512249.1 enoyl-CoA hydratase/isomerase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Pae0151-like, PIN domain

(9-124)

Antitoxin

Post-segregation antitoxin CcdA

(5-48)


Sequences

Toxin        


Download         Length: 131 a.a.        Molecular weight: 15015.68 Da        Isoelectric Point: 8.2956

>T26415 WP_014512246.1 NC_017275:c702812-702420 [Sulfolobus islandicus HVE10/4]
MKDKEFLFDASALYSLLDYVDKVDVKKIHILTLTLYEVGNVIWKEYYIHKKVKDPITLSTLFHKLMRKLNVVEDPPLDGV
MRIAVERSLTYYDASYAYVAESLGLILVSNDKELIRKANAISLKDLIKSM

Download         Length: 393 bp

>T26415 NC_017275:c702812-702420 [Sulfolobus islandicus HVE10/4]
ATGAAAGATAAGGAATTCCTATTCGATGCCTCAGCTTTGTACTCGCTTTTAGATTACGTGGATAAGGTAGATGTTAAGAA
AATTCATATACTTACCCTAACTCTTTATGAGGTAGGTAACGTTATATGGAAGGAGTATTATATACATAAAAAGGTTAAAG
ATCCTATAACTCTTTCGACGCTTTTCCATAAATTAATGCGAAAACTTAACGTAGTAGAGGACCCGCCTCTTGATGGAGTA
ATGAGAATTGCCGTAGAAAGGAGTTTGACTTACTATGACGCATCTTACGCATATGTTGCTGAATCTTTAGGGCTTATCCT
AGTGTCTAACGATAAAGAGCTGATAAGAAAAGCTAATGCCATTTCGCTAAAGGATTTGATAAAAAGTATGTGA

Antitoxin


Download         Length: 75 a.a.        Molecular weight: 8883.21 Da        Isoelectric Point: 4.8365

>AT26415 WP_014512247.1 NC_017275:c703026-702802 [Sulfolobus islandicus HVE10/4]
MSDVISVRVKKELKKRAEELGINIREVVEKALEEAIREKEKEELKDIAMRIKELMRDVSEDDWVWAVRESRDER

Download         Length: 225 bp

>AT26415 NC_017275:c703026-702802 [Sulfolobus islandicus HVE10/4]
ATGTCAGACGTAATAAGCGTAAGAGTTAAGAAAGAGCTGAAGAAGAGGGCAGAGGAGTTGGGAATTAACATTAGGGAGGT
TGTAGAAAAAGCTTTAGAAGAGGCCATAAGGGAGAAGGAGAAGGAAGAGCTTAAGGATATAGCTATGAGAATTAAGGAAC
TAATGAGGGATGTAAGTGAAGATGATTGGGTATGGGCTGTTAGGGAGAGTAGGGATGAAAGATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB F0NNP3

Antitoxin

Source ID Structure
AlphaFold DB F0NNP4

References