Detailed information of TA system TA026415

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/PIN-CcdA
• Location: 702420..703026
• Replicon: chromosome
• Accession: NC_017275
• Organism: Sulfolobus islandicus HVE10/4

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: F0NNP3
• Locus tag: SIH_RS03790
• Protein ID: WP_014512246.1
• Coordinates: 702420..702812 (-)
• Length: 131 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: F0NNP4
• Locus tag: SIH_RS03795
• Protein ID: WP_014512247.1
• Coordinates: 702802..703026 (-)
• Length: 75 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
SIH_RS03770 (SiH_0718)	697890..698864	+	975	WP_014512242.1	glycosyltransferase family A protein	-
SIH_RS03775 (SiH_0719)	698854..700185	-	1332	WP_014512243.1	APC family permease	-
SIH_RS03780 (SiH_0720)	700292..700867	-	576	WP_014512244.1	XdhC family protein	-
SIH_RS03785 (SiH_0721)	701618..702094	-	477	Protein_759	cytochrome b558/566 subunit B	-
SIH_RS03790 (SiH_0722)	702420..702812	-	393	WP_014512246.1	type II toxin-antitoxin system VapC family toxin	Toxin
SIH_RS03795 (SiH_0723)	702802..703026	-	225	WP_014512247.1	type II toxin-antitoxin system CcdA family antitoxin	Antitoxin
SIH_RS03800	703142..703845	-	704	Protein_762	helix-turn-helix domain-containing protein	-
SIH_RS03805 (SiH_0725)	704055..706322	-	2268	WP_014512248.1	xanthine dehydrogenase family protein molybdopterin-binding subunit	-
SIH_RS03810 (SiH_0726)	706325..707089	-	765	WP_014512249.1	enoyl-CoA hydratase/isomerase family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Pae0151-like, PIN domain (9-124)

Antitoxin

• Post-segregation antitoxin CcdA (5-48)

Sequences

Toxin

Protein

• Length: 131 a.a.
• Molecular weight: 15015.68 Da
• Isoelectric Point: 8.2956

>T26415 WP_014512246.1 NC_017275:c702812-702420 [Sulfolobus islandicus HVE10/4]
MKDKEFLFDASALYSLLDYVDKVDVKKIHILTLTLYEVGNVIWKEYYIHKKVKDPITLSTLFHKLMRKLNVVEDPPLDGV
MRIAVERSLTYYDASYAYVAESLGLILVSNDKELIRKANAISLKDLIKSM

Nucleotide

• Length: 393 bp

>T26415 NC_017275:c702812-702420 [Sulfolobus islandicus HVE10/4]
ATGAAAGATAAGGAATTCCTATTCGATGCCTCAGCTTTGTACTCGCTTTTAGATTACGTGGATAAGGTAGATGTTAAGAA
AATTCATATACTTACCCTAACTCTTTATGAGGTAGGTAACGTTATATGGAAGGAGTATTATATACATAAAAAGGTTAAAG
ATCCTATAACTCTTTCGACGCTTTTCCATAAATTAATGCGAAAACTTAACGTAGTAGAGGACCCGCCTCTTGATGGAGTA
ATGAGAATTGCCGTAGAAAGGAGTTTGACTTACTATGACGCATCTTACGCATATGTTGCTGAATCTTTAGGGCTTATCCT
AGTGTCTAACGATAAAGAGCTGATAAGAAAAGCTAATGCCATTTCGCTAAAGGATTTGATAAAAAGTATGTGA

Antitoxin

Protein

• Length: 75 a.a.
• Molecular weight: 8883.21 Da
• Isoelectric Point: 4.8365

>AT26415 WP_014512247.1 NC_017275:c703026-702802 [Sulfolobus islandicus HVE10/4]
MSDVISVRVKKELKKRAEELGINIREVVEKALEEAIREKEKEELKDIAMRIKELMRDVSEDDWVWAVRESRDER

Nucleotide

• Length: 225 bp

>AT26415 NC_017275:c703026-702802 [Sulfolobus islandicus HVE10/4]
ATGTCAGACGTAATAAGCGTAAGAGTTAAGAAAGAGCTGAAGAAGAGGGCAGAGGAGTTGGGAATTAACATTAGGGAGGT
TGTAGAAAAAGCTTTAGAAGAGGCCATAAGGGAGAAGGAGAAGGAAGAGCTTAAGGATATAGCTATGAGAATTAAGGAAC
TAATGAGGGATGTAAGTGAAGATGATTGGGTATGGGCTGTTAGGGAGAGTAGGGATGAAAGATAA

Structures

Toxin

• AlphaFold DB: F0NNP3

Antitoxin

• AlphaFold DB: F0NNP4