Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) vapBC/VapC(toxin)
Location 1742495..1742955 Replicon chromosome
Accession NZ_CP110674
Organism Mycobacterium tuberculosis strain BLR-31d

Toxin (Protein)


Gene name vapC Uniprot ID G0TKL9
Locus tag OO115_RS07955 Protein ID WP_003898996.1
Coordinates 1742707..1742955 (+) Length 83 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID P9WJ30
Locus tag OO115_RS07950 Protein ID WP_003408528.1
Coordinates 1742495..1742707 (+) Length 71 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

(2-69)


Sequences


Toxin        


Download         Length: 83 a.a.        Molecular weight: 8884.14 Da        Isoelectric Point: 4.1074

>T264148 WP_003898996.1 NZ_CP110674:1742707-1742955 [Mycobacterium tuberculosis]
MVIDTSALVAMLNDEPEAQRFEIAVAADHVWLMSTASYPEMATVIETRFGEPGGREPKVSGQPLLYKGDDFACIDIRAVL
AG

Download         Length: 249 bp


Antitoxin


Download         Length: 71 a.a.        Molecular weight: 7607.80 Da        Isoelectric Point: 9.3146

>AT264148 WP_003408528.1 NZ_CP110674:1742495-1742707 [Mycobacterium tuberculosis]
MELAARMGETLTQAVVVAVREQLARRTGRTRSISLREELAAIGRRCAALPVLDTRAADTILGYDERGLPA

Download         Length: 213 bp


Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB G0TKL9


Antitoxin

Source ID Structure
AlphaFold DB A0A829CFE8

References