Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VapB
Location 1547269..1547882 Replicon chromosome
Accession NZ_CP110674
Organism Mycobacterium tuberculosis strain BLR-31d

Toxin (Protein)


Gene name vapC Uniprot ID P64880
Locus tag OO115_RS07085 Protein ID WP_003407786.1
Coordinates 1547478..1547882 (+) Length 135 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A0E8UJ46
Locus tag OO115_RS07080 Protein ID WP_009935474.1
Coordinates 1547269..1547472 (+) Length 68 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OO115_RS07050 (OO115_07050) 1542674..1543054 + 381 WP_003407768.1 fumarate reductase subunit C -
OO115_RS07055 (OO115_07055) 1543051..1543428 + 378 WP_003407771.1 fumarate reductase subunit FrdD -
OO115_RS07060 (OO115_07060) 1543496..1544104 + 609 WP_003407773.1 TetR/AcrR family transcriptional regulator -
OO115_RS07065 (OO115_07065) 1544282..1545436 + 1155 Protein_1399 MMPL family transporter -
OO115_RS07070 (OO115_07070) 1545446..1545892 + 447 WP_003407780.1 F420H(2)-dependent quinone reductase -
OO115_RS07075 (OO115_07075) 1545927..1547216 + 1290 WP_003407781.1 threonine ammonia-lyase -
OO115_RS07080 (OO115_07080) 1547269..1547472 + 204 WP_009935474.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
OO115_RS07085 (OO115_07085) 1547478..1547882 + 405 WP_003407786.1 type II toxin-antitoxin system toxin ribonuclease VapC11 Toxin
OO115_RS07090 (OO115_07090) 1547899..1549641 - 1743 WP_003407788.1 malto-oligosyltrehalose trehalohydrolase -
OO115_RS07095 (OO115_07095) 1549634..1551931 - 2298 WP_003407790.1 malto-oligosyltrehalose synthase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-124)

Antitoxin

Bacterial antitoxin of type II TA system, VapB

(2-44)


Sequences

Toxin        


Download         Length: 135 a.a.        Molecular weight: 14650.76 Da        Isoelectric Point: 5.6587

>T264146 WP_003407786.1 NZ_CP110674:1547478-1547882 [Mycobacterium tuberculosis]
MILIDTSAWVEYFRATGSIAAVEVRRLLSEEAARIAMCEPIAMEILSGALDDNTHTTLERLVNGLPSLNVDDAIDFRAAA
GIYRAARRAGETVRSINDCLIAALAIRHGARIVHRDADFDVIARITNLQAASFR

Download         Length: 405 bp

Antitoxin


Download         Length: 68 a.a.        Molecular weight: 7501.48 Da        Isoelectric Point: 4.3951

>AT264146 WP_009935474.1 NZ_CP110674:1547269-1547472 [Mycobacterium tuberculosis]
MSRTNIDIDDELAAEVMRRFGLTTKRAAVDLALRRLVGSPLSREFLLGLEGVGWEGDLDDLRSDRPD

Download         Length: 204 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6A7V

Antitoxin

Source ID Structure
AlphaFold DB A0A0E8UJ46

References