264145

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 1468771..1469387 Replicon chromosome
Accession NZ_CP110674
Organism Mycobacterium tuberculosis strain BLR-31d

Toxin (Protein)


Gene name mazF Uniprot ID G0TJ74
Locus tag OO115_RS06740 Protein ID WP_003407593.1
Coordinates 1469070..1469387 (+) Length 106 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID G0TJ73
Locus tag OO115_RS06735 Protein ID WP_003900349.1
Coordinates 1468771..1469073 (+) Length 101 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OO115_RS06725 (OO115_06725) 1464657..1466504 + 1848 WP_003407585.1 methylmalonyl-CoA mutase small subunit -
OO115_RS06730 (OO115_06730) 1466505..1468757 + 2253 WP_003407587.1 methylmalonyl-CoA mutase -
OO115_RS06735 (OO115_06735) 1468771..1469073 + 303 WP_003900349.1 type II toxin-antitoxin system antitoxin MazE4 Antitoxin
OO115_RS06740 (OO115_06740) 1469070..1469387 + 318 WP_003407593.1 type II toxin-antitoxin system toxin endoribonuclease MazF4 Toxin
OO115_RS06745 (OO115_06745) 1469384..1470388 + 1005 WP_003407596.1 methylmalonyl Co-A mutase-associated GTPase MeaB -
OO115_RS06750 (OO115_06750) 1470441..1471730 + 1290 WP_003902090.1 serine hydrolase domain-containing protein -
OO115_RS06755 (OO115_06755) 1471803..1472528 - 726 WP_003898898.1 class I SAM-dependent methyltransferase -
OO115_RS06760 (OO115_06760) 1472634..1472846 - 213 WP_003898900.1 dodecin family protein -
OO115_RS06765 (OO115_06765) 1472907..1473305 + 399 WP_003900351.1 hypothetical protein -
OO115_RS06770 (OO115_06770) 1473350..1474378 + 1029 WP_003407612.1 glycosyltransferase family 2 protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(6-99)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 106 a.a.        Molecular weight: 11377.97 Da        Isoelectric Point: 7.9950

>T264145 WP_003407593.1 NZ_CP110674:1469070-1469387 [Mycobacterium tuberculosis]
VNAPLRGQVYRCDLGYGAKPWLIVSNNARNRHTADVVAVRLTTTRRTIPTWVAMGPSDPLTGYVNADNIETLGKDELGDY
LGEVTPATMNKINTALATALGLPWP

Download         Length: 318 bp

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 11173.42 Da        Isoelectric Point: 9.5564

>AT264145 WP_003900349.1 NZ_CP110674:1468771-1469073 [Mycobacterium tuberculosis]
VPFLVALSGIISGVRDHSMTVRLDQQTRQRLQDIVKGGYRSANAAIVDAINKRWEALHDEQLDAAYAAAIHDNPAYPYES
EAERSAARARRNARQQRSAQ

Download         Length: 303 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 5XE3
PDB 5XE2

Antitoxin

Source ID Structure
AlphaFold DB G0TJ73

References