264144

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1(toxin)
Location 1354808..1355463 Replicon chromosome
Accession NZ_CP110674
Organism Mycobacterium tuberculosis strain BLR-31d

Toxin (Protein)


Gene name vapC Uniprot ID P9WFA6
Locus tag OO115_RS06235 Protein ID WP_003898861.1
Coordinates 1354808..1355209 (-) Length 134 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID G0TIK2
Locus tag OO115_RS06240 Protein ID WP_003407272.1
Coordinates 1355206..1355463 (-) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OO115_RS06220 (OO115_06220) 1350280..1351665 - 1386 WP_003407260.1 cytochrome P450 -
OO115_RS06225 (OO115_06225) 1351743..1352777 + 1035 WP_003407264.1 AraC family transcriptional regulator -
OO115_RS06230 (OO115_06230) 1352823..1354553 - 1731 WP_009940170.1 PE family protein -
OO115_RS06235 (OO115_06235) 1354808..1355209 - 402 WP_003898861.1 type II toxin-antitoxin system VapC family toxin Toxin
OO115_RS06240 (OO115_06240) 1355206..1355463 - 258 WP_003407272.1 CopG family transcriptional regulator Antitoxin
OO115_RS06245 (OO115_06245) 1355546..1356505 - 960 WP_003407276.1 alpha/beta hydrolase -
OO115_RS06250 (OO115_06250) 1356530..1357492 - 963 WP_003905554.1 alpha/beta hydrolase -
OO115_RS06255 (OO115_06255) 1357491..1358228 + 738 WP_031647000.1 lysoplasmalogenase -
OO115_RS06260 (OO115_06260) 1358309..1360276 + 1968 WP_003407285.1 primosomal protein N' -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-108)

Antitoxin

Ribbon-helix-helix protein, CopG

(3-39)


Sequences

Toxin        


Download         Length: 134 a.a.        Molecular weight: 14952.43 Da        Isoelectric Point: 11.4656

>T264144 WP_003898861.1 NZ_CP110674:c1355209-1354808 [Mycobacterium tuberculosis]
MILVDSDVLIAHLRGVVAARDWLVSARKDGPLAISVVSTAELIGGMRTAERREVWRLLASFRVQPATEVIARRAGDMMRR
YRRSHNRIGLGDYLIAATADVQDLQLATLNVWHFPMFEQLKPPFAVPGHRPRA

Download         Length: 402 bp

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9443.58 Da        Isoelectric Point: 6.4631

>AT264144 WP_003407272.1 NZ_CP110674:c1355463-1355206 [Mycobacterium tuberculosis]
MKRTNIYLDEEQTASLDKLAAQEGVSRAELIRLLLNRALTTAGDDLASDLQAINDSFGTLRHLDPPVRRSGGREQHLAQV
WRATS

Download         Length: 258 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A045ISB0

Antitoxin

Source ID Structure
AlphaFold DB G0TIK2

References