Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PhRel-ATphRel/-
Location 1319087..1320137 Replicon chromosome
Accession NZ_CP110674
Organism Mycobacterium tuberculosis strain BLR-31d

Toxin (Protein)


Gene name phRel Uniprot ID G0TIH2
Locus tag OO115_RS06075 Protein ID WP_003407164.1
Coordinates 1319087..1319908 (+) Length 274 a.a.

Antitoxin (Protein)


Gene name ATphRel Uniprot ID A0A7U4BTV8
Locus tag OO115_RS06080 Protein ID WP_003407167.1
Coordinates 1319901..1320137 (+) Length 79 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OO115_RS06055 (OO115_06055) 1314645..1315307 - 663 WP_003407152.1 membrane protein -
OO115_RS06060 (OO115_06060) 1315304..1316089 - 786 WP_003407157.1 membrane protein -
OO115_RS06065 (OO115_06065) 1316380..1318341 - 1962 WP_003407159.1 sigma-F factor regulator -
OO115_RS06070 (OO115_06070) 1318480..1318866 - 387 WP_003898845.1 anti-sigma-F factor antagonist RsfA -
OO115_RS06075 (OO115_06075) 1319087..1319908 + 822 WP_003407164.1 GTP pyrophosphokinase family protein Toxin
OO115_RS06080 (OO115_06080) 1319901..1320137 + 237 WP_003407167.1 hypothetical protein Antitoxin
OO115_RS06085 (OO115_06085) 1320209..1321414 - 1206 WP_003918234.1 serine hydrolase domain-containing protein -
OO115_RS06090 (OO115_06090) 1321717..1322502 + 786 WP_003902048.1 lipoprotein LprF -
OO115_RS06095 (OO115_06095) 1322698..1323312 + 615 Protein_1205 cytochrome b5-like heme/steroid binding domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

RelA/SpoT

(76-174)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 274 a.a.        Molecular weight: 30100.10 Da        Isoelectric Point: 5.8187

>T264143 WP_003407164.1 NZ_CP110674:1319087-1319908 [Mycobacterium tuberculosis]
VVVALVGSAIVDLHSRPPWSNNAVRRLGVALRDGVDPPVDCPSYAEVMLWHADLAAEVQDRIEGRSWSASELLVTSRAKS
QDTLLAKLRRRPYLQLNTIQDIAGVRIDADLLLGEQTRLAREIADHFGADQPAIHDLRDHPHAGYRAVHVWLRLPAGRVE
IQIRTILQSLWANFYELLADAYGRGIRYDERPEQLAAGVVPAQLQELVGVMQDASADLAMHEAEWQHCAEIEYPGQRAMA
LGEASKNKATVLATTKFRLERAINEAESAGGGG

Download         Length: 822 bp

Antitoxin


Download         Length: 79 a.a.        Molecular weight: 8830.90 Da        Isoelectric Point: 7.3178

>AT264143 WP_003407167.1 NZ_CP110674:1319901-1320137 [Mycobacterium tuberculosis]
VGEVAGYVVEYNRRTHVRRITEFATPQEAMEHRLKLEAERTDSNIEIVALVSKSLGTLKQTHSRYFTGEELNVGNGAR

Download         Length: 237 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0TIH2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4BTV8

References