264142

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE-Phd
Location 1167797..1168356 Replicon chromosome
Accession NZ_CP110674
Organism Mycobacterium tuberculosis strain BLR-31d

Toxin (Protein)


Gene name relE Uniprot ID G0THS1
Locus tag OO115_RS05420 Protein ID WP_003898789.1
Coordinates 1167797..1168090 (-) Length 98 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID G0THS2
Locus tag OO115_RS05425 Protein ID WP_003406322.1
Coordinates 1168087..1168356 (-) Length 90 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OO115_RS05395 (OO115_05395) 1163495..1163755 + 261 WP_003406302.1 type II toxin-antitoxin system antitoxin VapB33 -
OO115_RS05400 (OO115_05400) 1163752..1164183 + 432 WP_003406304.1 type II toxin-antitoxin system VapC family toxin -
OO115_RS05405 (OO115_05405) 1164206..1165789 - 1584 WP_009940130.1 PE family protein -
OO115_RS05410 (OO115_05410) 1165969..1166829 + 861 WP_003900301.1 glycine betaine ABC transporter substrate-binding protein -
OO115_RS05415 (OO115_05415) 1166910..1167740 - 831 WP_003898788.1 SDR family NAD(P)-dependent oxidoreductase -
OO115_RS05420 (OO115_05420) 1167797..1168090 - 294 WP_003898789.1 type II toxin-antitoxin system mRNA interferase RelE Toxin
OO115_RS05425 (OO115_05425) 1168087..1168356 - 270 WP_003406322.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
OO115_RS05430 (OO115_05430) 1168469..1172164 - 3696 WP_003406323.1 multifunctional oxoglutarate decarboxylase/oxoglutarate dehydrogenase thiamine pyrophosphate-binding subunit/dihydrolipoyllysine-residue succinyltransferase subunit -
OO115_RS05435 (OO115_05435) 1172306..1173094 - 789 WP_003406325.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(9-88)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-73)


Sequences

Toxin        


Download         Length: 98 a.a.        Molecular weight: 11031.57 Da        Isoelectric Point: 9.6275

>T264142 WP_003898789.1 NZ_CP110674:c1168090-1167797 [Mycobacterium tuberculosis]
VSDDHPYHVAITATAARDLQRLPEKIAAACVEFVFGPLLNNPHRLGKPLRNDLEGLHSARRGDYRVVYAIDDGHHRVEII
HIARRSASYRMNPCRPR

Download         Length: 294 bp

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 9766.97 Da        Isoelectric Point: 4.8615

>AT264142 WP_003406322.1 NZ_CP110674:c1168356-1168087 [Mycobacterium tuberculosis]
MAVVPLGEVRNRLSEYVAEVELTHERITITRHGHPAAVLISADDLASIEETLEVLRTPGASEAIREGLADVAAGRFVSND
EIRNRYTAR

Download         Length: 270 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0THS1

Antitoxin

Source ID Structure
AlphaFold DB G0THS2

References