264141

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 1163495..1164183 Replicon chromosome
Accession NZ_CP110674
Organism Mycobacterium tuberculosis strain BLR-31d

Toxin (Protein)


Gene name vapC Uniprot ID G0THR7
Locus tag OO115_RS05400 Protein ID WP_003406304.1
Coordinates 1163752..1164183 (+) Length 144 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID G0THR6
Locus tag OO115_RS05395 Protein ID WP_003406302.1
Coordinates 1163495..1163755 (+) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OO115_RS05375 (OO115_05375) 1159072..1159896 + 825 WP_003900298.1 trehalose ABC transporter permease SugB -
OO115_RS05380 (OO115_05380) 1159901..1161082 + 1182 WP_003406299.1 trehalose ABC transporter ATP-binding protein SugC -
OO115_RS05385 (OO115_05385) 1161159..1162259 - 1101 WP_003406300.1 magnesium/cobalt transporter CorA -
OO115_RS05390 (OO115_05390) 1162430..1163419 + 990 WP_003406301.1 malate dehydrogenase -
OO115_RS05395 (OO115_05395) 1163495..1163755 + 261 WP_003406302.1 type II toxin-antitoxin system antitoxin VapB33 Antitoxin
OO115_RS05400 (OO115_05400) 1163752..1164183 + 432 WP_003406304.1 type II toxin-antitoxin system VapC family toxin Toxin
OO115_RS05405 (OO115_05405) 1164206..1165789 - 1584 WP_009940130.1 PE family protein -
OO115_RS05410 (OO115_05410) 1165969..1166829 + 861 WP_003900301.1 glycine betaine ABC transporter substrate-binding protein -
OO115_RS05415 (OO115_05415) 1166910..1167740 - 831 WP_003898788.1 SDR family NAD(P)-dependent oxidoreductase -
OO115_RS05420 (OO115_05420) 1167797..1168090 - 294 WP_003898789.1 type II toxin-antitoxin system mRNA interferase RelE -
OO115_RS05425 (OO115_05425) 1168087..1168356 - 270 WP_003406322.1 type II toxin-antitoxin system Phd/YefM family antitoxin -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain toxin

(2-142)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 144 a.a.        Molecular weight: 15873.08 Da        Isoelectric Point: 5.8838

>T264141 WP_003406304.1 NZ_CP110674:1163752-1164183 [Mycobacterium tuberculosis]
VIIPDINLLLYAVITGFPQHRRAHAWWQDTVNGHTRIGLTYPALFGFLRIATSARVLAAPLPTADAIAYVREWLSQPNVD
LLTAGPRHLDIALGLLDKLGTASHLTTDVQLAAYGIEYDAEIHSSDTDFARFADLKWTDPLRE

Download         Length: 432 bp

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9918.25 Da        Isoelectric Point: 6.4755

>AT264141 WP_003406302.1 NZ_CP110674:1163495-1163755 [Mycobacterium tuberculosis]
MRTTLTLDDDVVRLVEDAVHRERRPMKQVINDALRRALAPPVKRQEQYRLEPHESAVRSGLDLAGFNKLADELEDEALLD
ATRRAR

Download         Length: 261 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0THR7

Antitoxin

Source ID Structure
AlphaFold DB G0THR6

References