Detailed information of TA system TA026414

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/HTH_10(toxin)
• Location: 684975..685954
• Replicon: chromosome
• Accession: NC_017275
• Organism: Sulfolobus islandicus HVE10/4

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: M9U7R2
• Locus tag: SIH_RS03685
• Protein ID: WP_014512230.1
• Coordinates: 685340..685954 (+)
• Length: 205 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: M9U539
• Locus tag: SIH_RS03680
• Protein ID: WP_014512229.1
• Coordinates: 684975..685322 (+)
• Length: 116 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
SIH_RS03650 (SiH_0697)	680071..681267	+	1197	WP_014512224.1	MFS transporter	-
SIH_RS03655 (SiH_0698)	681212..682150	+	939	WP_014512225.1	dipeptidase	-
SIH_RS03660 (SiH_0699)	682468..682899	+	432	WP_014512226.1	universal stress protein	-
SIH_RS15360	682997..683119	-	123	WP_237702665.1	hypothetical protein	-
SIH_RS03670 (SiH_0700)	683264..684459	+	1196	Protein_736	transposase	-
SIH_RS14485	684469..684585	-	117	Protein_737	iron-sulfur cluster assembly protein	-
SIH_RS03675 (SiH_0701)	684676..684906	+	231	WP_014512228.1	C2H2-type zinc finger protein	-
SIH_RS03680 (SiH_0702)	684975..685322	+	348	WP_014512229.1	DUF488 domain-containing protein	Antitoxin
SIH_RS03685 (SiH_0703)	685340..685954	+	615	WP_014512230.1	helix-turn-helix domain-containing protein	Toxin
SIH_RS03690 (SiH_0704)	685998..686273	-	276	WP_014512231.1	hypothetical protein	-
SIH_RS15365	686398..686592	+	195	WP_014513669.1	hypothetical protein	-
SIH_RS03705 (SiH_0705)	687248..688012	+	765	WP_014512232.1	plastocyanin/azurin family copper-binding protein	-
SIH_RS03710 (SiH_0706)	688016..688339	+	324	WP_014512233.1	hypothetical protein	-
SIH_RS03715 (SiH_0707)	688320..688547	-	228	WP_014512234.1	hypothetical protein	-
SIH_RS03720 (SiH_0708)	688795..689394	+	600	WP_014512235.1	DUF2249 domain-containing protein	-
SIH_RS15160	689491..689685	+	195	WP_193385885.1	hypothetical protein	-
SIH_RS03725 (SiH_0709)	689752..689973	+	222	WP_014512236.1	hypothetical protein	-
SIH_RS03730 (SiH_0710)	689993..690817	+	825	WP_014512237.1	DMT family transporter	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	flank	IS/Tn	-	-	683350..684459	1109

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Bacterioopsin activator-type, HTH domain (145-197)

Antitoxin

• Protein of unknown function DUF488 (3-108)

Sequences

Toxin

Protein

• Length: 205 a.a.
• Molecular weight: 23353.44 Da
• Isoelectric Point: 9.4585

>T26414 WP_014512230.1 NC_017275:685340-685954 [Sulfolobus islandicus HVE10/4]
MLKSPFEVTILIEDHPCEVMGVISSTGLKATVDNVKLGDNTTDHIVLFEKEVQKDDLIKLKSHSIKVLKFNDSKVWVRTK
GCSVCKILYSSNVVVEKIKVIKERTLLYTLLVPNTIAFKEFLANLTSQRIKFTVLSTYEISSNDLTDRQMEILKLAYKMG
YFDDDRRVTLTELAKQLGISTPTLEEIMRRALRKVVKYYLDKVG

Nucleotide

• Length: 615 bp

>T26414 NC_017275:685340-685954 [Sulfolobus islandicus HVE10/4]
ATGTTAAAATCACCGTTCGAAGTAACAATCTTGATTGAAGATCACCCTTGTGAGGTTATGGGAGTAATATCTAGTACTGG
GCTTAAAGCAACTGTTGACAACGTTAAACTCGGGGATAATACAACTGATCACATAGTCCTTTTCGAAAAAGAGGTCCAAA
AAGATGATCTAATTAAACTTAAGTCCCATAGTATCAAAGTCTTAAAGTTTAATGATAGCAAAGTATGGGTTAGAACTAAG
GGATGCTCAGTATGTAAGATTCTCTATTCTTCAAATGTTGTCGTAGAGAAAATAAAAGTAATAAAAGAGAGAACATTACT
CTATACGCTTTTGGTCCCTAATACGATAGCTTTTAAGGAGTTTCTAGCTAATCTTACTAGTCAAAGGATAAAGTTTACAG
TCCTAAGCACCTATGAAATAAGCAGTAACGACTTAACTGATAGACAAATGGAAATATTGAAACTTGCATACAAGATGGGT
TATTTTGATGATGATAGGAGAGTAACTTTAACTGAATTAGCAAAGCAATTGGGAATATCAACTCCGACTTTGGAGGAAAT
TATGAGGAGAGCGTTAAGGAAAGTCGTCAAGTATTATTTAGATAAAGTAGGGTAA

Antitoxin

Protein

• Length: 116 a.a.
• Molecular weight: 13678.98 Da
• Isoelectric Point: 9.8667

>AT26414 WP_014512229.1 NC_017275:684975-685322 [Sulfolobus islandicus HVE10/4]
MIKIKRVYDPIEKDDGLRVLVDRLWPRGIGKNKVDLWLKDIAPSDELRKWYGHDASKWDEFKRKYFEELDANPKMSILLQ
LIRKGENITLLYASKSPYNNAIALKEYLEKKILKE

Nucleotide

• Length: 348 bp

>AT26414 NC_017275:684975-685322 [Sulfolobus islandicus HVE10/4]
ATGATTAAGATAAAGAGGGTTTACGATCCAATAGAGAAAGATGACGGACTAAGAGTCTTAGTGGATAGGTTATGGCCAAG
AGGAATTGGCAAAAATAAGGTGGATTTATGGCTTAAAGATATAGCACCCAGTGATGAGTTACGAAAATGGTACGGTCATG
ATGCCAGTAAATGGGATGAGTTCAAAAGGAAATATTTTGAGGAACTAGATGCTAATCCAAAGATGAGTATTTTATTACAA
TTAATTAGAAAGGGCGAAAATATTACCTTACTTTACGCCTCCAAATCACCGTATAATAATGCAATTGCGTTAAAGGAGTA
TCTAGAGAAAAAGATATTAAAAGAATAG

Structures

Toxin

• AlphaFold DB: M9U7R2

Antitoxin

• AlphaFold DB: M9U539