264132

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC(toxin)
Location 362162..362805 Replicon chromosome
Accession NZ_CP110674
Organism Mycobacterium tuberculosis strain BLR-31d

Toxin (Protein)


Gene name vapC Uniprot ID P9WFB8
Locus tag OO115_RS01580 Protein ID WP_003401566.1
Coordinates 362380..362805 (+) Length 142 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID O07227
Locus tag OO115_RS01575 Protein ID WP_003401563.1
Coordinates 362162..362383 (+) Length 74 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OO115_RS01550 (OO115_01550) 357281..358084 - 804 WP_003401540.1 Stf0 family sulphotransferase -
OO115_RS01555 (OO115_01555) 358094..359491 - 1398 WP_003401544.1 sulfatase -
OO115_RS01560 (OO115_01560) 359670..361445 + 1776 WP_010886074.1 PE family protein -
OO115_RS01565 (OO115_01565) 361588..361815 + 228 WP_003401555.1 ribbon-helix-helix protein, CopG family -
OO115_RS01570 (OO115_01570) 361812..362114 + 303 WP_003401560.1 toxin-antitoxin system toxin -
OO115_RS01575 (OO115_01575) 362162..362383 + 222 WP_003401563.1 type II toxin-antitoxin system antitoxin VapB2 Antitoxin
OO115_RS01580 (OO115_01580) 362380..362805 + 426 WP_003401566.1 PIN domain nuclease Toxin
OO115_RS01585 (OO115_01585) 362941..363573 + 633 WP_003905275.1 TetR/AcrR family transcriptional regulator -
OO115_RS01590 (OO115_01590) 363570..364478 + 909 WP_003900117.1 protochlorophyllide reductase -
OO115_RS01595 (OO115_01595) 364486..365076 - 591 WP_229298012.1 hypothetical protein -
OO115_RS01600 (OO115_01600) 365069..365119 - 51 Protein_316 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(7-125)

Antitoxin

Ribbon-helix-helix protein, CopG

(9-37)


Sequences

Toxin        


Download         Length: 142 a.a.        Molecular weight: 15713.90 Da        Isoelectric Point: 5.6002

>T264132 WP_003401566.1 NZ_CP110674:362380-362805 [Mycobacterium tuberculosis]
VTDQRWLIDKSALVRLTDSPDMEIWSNRIERGLVHITGVTRLEVGFSAECGEIARREFREPPLSAMPVEYLTPRIEDRAL
EVQTLLADRGHHRGPSIPDLLIAATAELSGLTVLHVDKDFDAIAALTGQKTERLTHRPPSA

Download         Length: 426 bp

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 8088.31 Da        Isoelectric Point: 10.7177

>AT264132 WP_003401563.1 NZ_CP110674:362162-362383 [Mycobacterium tuberculosis]
MSDVLIRDIPDDVLASLDAIAARLGLSRTEYIRRRLAQDAQTARVTVTAADLRRLRGAVAGLGDPELMRQAWR

Download         Length: 222 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 3H87

Antitoxin

Source ID Structure
AlphaFold DB A0A829CG48

References