Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 3810908..3812479 Replicon chromosome
Accession NZ_CP110673
Organism Proteus mirabilis strain DP2019

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag OOZ57_RS17360 Protein ID WP_049213398.1
Coordinates 3810908..3812221 (-) Length 438 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag OOZ57_RS17365 Protein ID WP_049203075.1
Coordinates 3812222..3812479 (-) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OOZ57_RS17340 (OOZ57_17340) 3806078..3806881 + 804 WP_161680118.1 energy transducer TonB -
OOZ57_RS17345 (OOZ57_17345) 3806935..3808896 - 1962 WP_012368635.1 insecticidal delta-endotoxin Cry8Ea1 family protein -
OOZ57_RS17350 (OOZ57_17350) 3808928..3809857 - 930 WP_004246518.1 metallophosphoesterase -
OOZ57_RS17355 (OOZ57_17355) 3810042..3810506 - 465 WP_004249773.1 DUF1097 domain-containing protein -
OOZ57_RS17360 (OOZ57_17360) 3810908..3812221 - 1314 WP_049213398.1 type II toxin-antitoxin system HipA family toxin Toxin
OOZ57_RS17365 (OOZ57_17365) 3812222..3812479 - 258 WP_049203075.1 helix-turn-helix domain-containing protein Antitoxin
OOZ57_RS17370 (OOZ57_17370) 3812628..3813992 - 1365 WP_004246513.1 tRNA uridine-5-carboxymethylaminomethyl(34) synthesis GTPase MnmE -
OOZ57_RS17375 (OOZ57_17375) 3814130..3815770 - 1641 WP_004246512.1 membrane protein insertase YidC -
OOZ57_RS17380 (OOZ57_17380) 3815773..3816033 - 261 WP_012368639.1 membrane protein insertion efficiency factor YidD -
OOZ57_RS17385 (OOZ57_17385) 3815997..3816356 - 360 WP_004246510.1 ribonuclease P protein component -
OOZ57_RS17390 (OOZ57_17390) 3816374..3816517 - 144 WP_004246509.1 50S ribosomal protein L34 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(4-103)

Antitoxin

Cro/C1-type helix-turn-helix domain

(13-65)


Sequences

Toxin        


Download         Length: 438 a.a.        Molecular weight: 49647.74 Da        Isoelectric Point: 6.4174

>T264128 WP_049213398.1 NZ_CP110673:c3812221-3810908 [Proteus mirabilis]
MASLDVYMNEYYVGIFTKKSSGAHSFQYTEDWVNQPGSRPISLSMPLQLQEYQGDCVYNFFDNLLPDNTEIRNRIVSRYN
ANSNQPFDLLAAIGADTVGALRLLPSGSTPANIKKIEYQKLNDIELEKILLGYKSNTPLGMLKEYTDFRISIAGAQEKTA
LLLKDNDWCVPHNNTPTTHIIKLPIGVIESHSYTMDLSNSVENEYLCTLIAKEFDLPVPHCSIIKTKNVKALAVERFDRK
YSSDKSWIIRLPQEDFCQILNIPSALKYENEGGPGIIDIMKYLLGSSNADQDRFHFMKAQVLFWLLAATDGHAKNFSVFI
NQEGRFHLTPLYDIMSIYPNFGGRGLNPRDAKLAMGLKASRGKKYAIEQIFPRHFYQTAEAVGFDPSLMSDILRYFYQEM
DDVIQRVKQQLPEDFPSEISNTILDGMKARAVRLANI

Download         Length: 1314 bp

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9878.43 Da        Isoelectric Point: 10.0139

>AT264128 WP_049203075.1 NZ_CP110673:c3812479-3812222 [Proteus mirabilis]
MIIINAYQLSVHLKDVRLTKKLSQSKVAQKVGIRQDTVSNFEINPNSTKLETFFKLLSALNLEMEIHPKDAKNNLAHKSE
WKEEW

Download         Length: 258 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References