Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vagCD/VapC-VagC
Location 3534307..3534956 Replicon chromosome
Accession NZ_CP110673
Organism Proteus mirabilis strain DP2019

Toxin (Protein)


Gene name vagD Uniprot ID -
Locus tag OOZ57_RS16150 Protein ID WP_049256512.1
Coordinates 3534307..3534726 (-) Length 140 a.a.

Antitoxin (Protein)


Gene name vagC Uniprot ID B4EZC0
Locus tag OOZ57_RS16155 Protein ID WP_012368535.1
Coordinates 3534723..3534956 (-) Length 78 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OOZ57_RS16120 (OOZ57_16120) 3529584..3530462 - 879 WP_004246812.1 23S rRNA pseudouridine(2604) synthase RluF -
OOZ57_RS16125 (OOZ57_16125) 3530638..3531552 - 915 WP_004249085.1 fatty acid biosynthesis protein FabY -
OOZ57_RS16130 (OOZ57_16130) 3531576..3532013 - 438 WP_004246810.1 D-aminoacyl-tRNA deacylase -
OOZ57_RS16135 (OOZ57_16135) 3532094..3532711 - 618 WP_004246809.1 glucose-1-phosphatase -
OOZ57_RS16140 (OOZ57_16140) 3533365..3533781 - 417 WP_049208252.1 hypothetical protein -
OOZ57_RS16145 (OOZ57_16145) 3533759..3534082 - 324 WP_049208253.1 hypothetical protein -
OOZ57_RS16150 (OOZ57_16150) 3534307..3534726 - 420 WP_049256512.1 type II toxin-antitoxin system VapC family toxin Toxin
OOZ57_RS16155 (OOZ57_16155) 3534723..3534956 - 234 WP_012368535.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
OOZ57_RS16160 (OOZ57_16160) 3535223..3535375 + 153 WP_162837551.1 hypothetical protein -
OOZ57_RS16165 (OOZ57_16165) 3535707..3537542 - 1836 WP_004246802.1 ribosome-dependent GTPase TypA -
OOZ57_RS16170 (OOZ57_16170) 3537902..3539311 + 1410 WP_004246801.1 glutamate--ammonia ligase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-129)

Antitoxin

SpoVT-AbrB domain

(9-56)


Sequences

Toxin        


Download         Length: 140 a.a.        Molecular weight: 15401.91 Da        Isoelectric Point: 7.7288

>T264127 WP_049256512.1 NZ_CP110673:c3534726-3534307 [Proteus mirabilis]
VKKVYMLDTNICSFIMREQPISLLEKLQKCVMNHDTIVISTITYSEMRFGAIGKKASPKHNRLVDAFCERVDAILAWDKA
AVDATTVIKKCLSDVGLPIGNNDSAIAGHAVAVNAILVTNNTREFSRVEGLKIEDWTHV

Download         Length: 420 bp

Antitoxin


Download         Length: 78 a.a.        Molecular weight: 8890.06 Da        Isoelectric Point: 4.4870

>AT264127 WP_012368535.1 NZ_CP110673:c3534956-3534723 [Proteus mirabilis]
MRTRTVAVFKNGSNRAIRLPKDFDFDGVNELEISRDGDCIILRPVKPNWISLQNEEKADSDFLLERDDVIEEGRVIL

Download         Length: 234 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB B4EZC0

References