Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/Doc-RelB
Location 11797..12398 Replicon chromosome
Accession NZ_CP110673
Organism Proteus mirabilis strain DP2019

Toxin (Protein)


Gene name doc Uniprot ID -
Locus tag OOZ57_RS00050 Protein ID WP_049194960.1
Coordinates 11797..12180 (-) Length 128 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID A0A1Z1SPN9
Locus tag OOZ57_RS00055 Protein ID WP_004246496.1
Coordinates 12177..12398 (-) Length 74 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OOZ57_RS00030 (OOZ57_00030) 7730..8293 + 564 WP_012368640.1 rRNA adenine N-6-methyltransferase family protein -
OOZ57_RS00035 (OOZ57_00035) 8569..9468 + 900 WP_265496920.1 N-acetylmuramic acid 6-phosphate etherase -
OOZ57_RS00040 (OOZ57_00040) 9825..11063 - 1239 WP_020946511.1 HipA domain-containing protein -
OOZ57_RS00045 (OOZ57_00045) 11076..11390 - 315 WP_004246498.1 helix-turn-helix transcriptional regulator -
OOZ57_RS00050 (OOZ57_00050) 11797..12180 - 384 WP_049194960.1 type II toxin-antitoxin system death-on-curing family toxin Toxin
OOZ57_RS00055 (OOZ57_00055) 12177..12398 - 222 WP_004246496.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
OOZ57_RS00060 (OOZ57_00060) 12679..13542 - 864 WP_004249947.1 YicC/YloC family endoribonuclease -
OOZ57_RS00065 (OOZ57_00065) 13669..14385 + 717 WP_004249946.1 ribonuclease PH -
OOZ57_RS00070 (OOZ57_00070) 14466..15110 + 645 WP_004246493.1 orotate phosphoribosyltransferase -
OOZ57_RS00075 (OOZ57_00075) 15429..16034 - 606 WP_004246491.1 nucleoid occlusion factor SlmA -
OOZ57_RS00080 (OOZ57_00080) 16154..16612 - 459 WP_004246490.1 dUTP diphosphatase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Death on curing protein

(5-115)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-52)


Sequences

Toxin        


Download         Length: 128 a.a.        Molecular weight: 14462.43 Da        Isoelectric Point: 6.6451

>T264125 WP_049194960.1 NZ_CP110673:c12180-11797 [Proteus mirabilis]
MIWVSAQEVIAFHDRILQHFPGVAGMSDPGRAEALIYRVQNRKHDEGITDVFELAATYWVAIARGHIFNDGNKRTAFFVT
MTFLYRNGIRIRDTDNMLENLTVEAATGEKTVDQLAKHLQNLVEKTN

Download         Length: 384 bp

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 8260.23 Da        Isoelectric Point: 5.5667

>AT264125 WP_004246496.1 NZ_CP110673:c12398-12177 [Proteus mirabilis]
MRTYTSTQARANISEVLDIATHGEPVEITRRDGCSAVVISKTEFESYQNAKLDAEFDMMMQRHGHTVEALTNR

Download         Length: 222 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A1Z1SPN9

References