Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mosAT/AbiEii-AbiEi
Location 752764..754486 Replicon chromosome
Accession NZ_CP110670
Organism Vibrio alginolyticus strain AUSMDU00064140

Toxin (Protein)


Gene name mosT Uniprot ID -
Locus tag OPR71_RS03530 Protein ID WP_169618686.1
Coordinates 753548..754486 (+) Length 313 a.a.

Antitoxin (Protein)


Gene name mosA Uniprot ID -
Locus tag OPR71_RS03525 Protein ID WP_108947368.1
Coordinates 752764..753540 (+) Length 259 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OPR71_RS03495 (OPR71_03495) 748438..748719 + 282 WP_000433889.1 type IV conjugative transfer system protein TraL -
OPR71_RS03500 (OPR71_03500) 748716..749342 + 627 WP_267923026.1 TraE/TraK family type IV conjugative transfer system protein -
OPR71_RS03505 (OPR71_03505) 749326..750222 + 897 WP_267923157.1 type-F conjugative transfer system secretin TraK -
OPR71_RS03510 (OPR71_03510) 750225..751514 + 1290 WP_267923027.1 TraB/VirB10 family protein -
OPR71_RS03515 (OPR71_03515) 751589..752161 + 573 WP_146008853.1 type IV conjugative transfer system lipoprotein TraV -
OPR71_RS03520 (OPR71_03520) 752158..752544 + 387 WP_000180225.1 TraA family conjugative transfer protein -
OPR71_RS03525 (OPR71_03525) 752764..753540 + 777 WP_108947368.1 type IV toxin-antitoxin system AbiEi family antitoxin Antitoxin
OPR71_RS03530 (OPR71_03530) 753548..754486 + 939 WP_169618686.1 nucleotidyl transferase AbiEii/AbiGii toxin family protein Toxin
OPR71_RS03535 (OPR71_03535) 755065..757794 + 2730 WP_108947341.1 DEAD/DEAH box helicase -
OPR71_RS03540 (OPR71_03540) 757791..758900 + 1110 WP_108947342.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element tet(59) / ARR-3 / dfrA27 / aadA16 / qacE / sul1 / blaNDM-1 / catA2 - 686737..802878 116141


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Nucleotidyl transferase AbiEii toxin, Type IV TA system

(14-278)

Antitoxin

Transcriptional regulator AbiEi antitoxin, N-terminal domain

(1-97)


Sequences

Toxin        


Download         Length: 313 a.a.        Molecular weight: 35509.81 Da        Isoelectric Point: 5.0003

>T264122 WP_169618686.1 NZ_CP110670:753548-754486 [Vibrio alginolyticus]
MDKYSPYYKQVSLLIRMLPVVATETVFALKGGTAINLFVKDFPRLSVDIDLAYLPLEPRDEALINVRAALQRITDRINTQ
PDIRAAFQDNKADELRIVVSSPVATIKIEVSPVARGTLHSAEVMPVQESVEDEFGYAEIQVVSLPDLYGGKLCAAMDRQH
PRDLFDVRMLLGSEGISREILVGFLTYTLSHPRPINEVMSPNWQPLNEKFQAEFDGMTFEKVECEDLASVRPIMLIELQK
HFTERDHAFLMSFKRGQPDWALFDYPSAADLPAIRWKLQNINKLAKNQAKHQEQLDKLKQVLDDWLVNANAE

Download         Length: 939 bp

Antitoxin


Download         Length: 259 a.a.        Molecular weight: 29564.95 Da        Isoelectric Point: 9.3775

>AT264122 WP_108947368.1 NZ_CP110670:752764-753540 [Vibrio alginolyticus]
MSSKINWLVAHTSPGALVLQQWLTENGVSYSLAQKYAQNGWLKKLCSGVYYRPDAQGDIKPTWVDAIQALDVQLGVSVHL
AGLSSLTHQGLSHYLQLNKEQVWVCVKNKSSLPKWFREFPYQNWFYCGNHKLEVNPEKDLKRITVKEKELTVSCAELAAY
EVVDAIGKLISFEHVAELFQGLVNLSPRKVQDILERSSSVQANRIFLFLGRYYDHQWVNRIDETRIKLGAGKRQVVEKGR
FDERYQITVPEILSVKRG

Download         Length: 777 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References