Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-YefM
Location 2124920..2125635 Replicon chromosome
Accession NZ_CP110664
Organism Actinobacillus pleuropneumoniae strain AP_123

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag OOL18_RS10295 Protein ID WP_052245676.1
Coordinates 2124920..2125285 (-) Length 122 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID B0BT01
Locus tag OOL18_RS10300 Protein ID WP_005599447.1
Coordinates 2125348..2125635 (-) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OOL18_RS10280 2120505..2122211 - 1707 WP_237592765.1 bifunctional (p)ppGpp synthetase/guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase -
OOL18_RS10285 2122307..2122588 - 282 WP_005599441.1 DNA-directed RNA polymerase subunit omega -
OOL18_RS10290 2122715..2124796 - 2082 WP_265410815.1 ATP-dependent DNA helicase RecG -
OOL18_RS10295 2124920..2125285 - 366 WP_052245676.1 type II toxin-antitoxin system VapC family toxin Toxin
OOL18_RS10300 2125348..2125635 - 288 WP_005599447.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
OOL18_RS10305 2125841..2127556 + 1716 WP_039709409.1 proline--tRNA ligase -
OOL18_RS10310 2127622..2127810 - 189 WP_005602684.1 hypothetical protein -
OOL18_RS10315 2127813..2128394 - 582 WP_005606496.1 sigma-70 family RNA polymerase sigma factor -
OOL18_RS10320 2128483..2129439 + 957 WP_005619040.1 protein-methionine-sulfoxide reductase catalytic subunit MsrP -
OOL18_RS10325 2129439..2130032 + 594 WP_005599453.1 protein-methionine-sulfoxide reductase heme-binding subunit MsrQ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-109)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 122 a.a.        Molecular weight: 14015.04 Da        Isoelectric Point: 7.9017

>T264120 WP_052245676.1 NZ_CP110664:c2125285-2124920 [Actinobacillus pleuropneumoniae]
IDTNVRQWLETIKPSQTNISCITLSEIKTGILLKARKDPIQAERLNHWFTHDVLSVYQAKSFSINNEIALLASEYHIPNK
MDLNDAYIAATAKYHNLVLVTRNLKDFNRCDIRLFNPFEPN

Download         Length: 366 bp

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 11040.29 Da        Isoelectric Point: 4.5578

>AT264120 WP_005599447.1 NZ_CP110664:c2125635-2125348 [Actinobacillus pleuropneumoniae]
MPITITSREFNQHASKVLKMAEKEPVFITKWGKIVSVVSNYVDYKQHTTVEPSFEELFASSTDESVSDEFWQDFEQTLTK
IRKSNKSEQIDFGDE

Download         Length: 288 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A3N3C5

References