Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 2028339..2028967 Replicon chromosome
Accession NZ_CP110664
Organism Actinobacillus pleuropneumoniae strain AP_123

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag OOL18_RS09700 Protein ID WP_005609156.1
Coordinates 2028569..2028967 (+) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag OOL18_RS09695 Protein ID WP_039709385.1
Coordinates 2028339..2028569 (+) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OOL18_RS09685 2026187..2027620 + 1434 WP_265410803.1 hypothetical protein -
OOL18_RS09690 2028091..2028231 - 141 WP_162835170.1 hypothetical protein -
OOL18_RS09695 2028339..2028569 + 231 WP_039709385.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
OOL18_RS09700 2028569..2028967 + 399 WP_005609156.1 tRNA(fMet)-specific endonuclease VapC Toxin
OOL18_RS09705 2029102..2029518 - 417 WP_215577975.1 DUF417 family protein -
OOL18_RS09710 2029764..2030414 + 651 WP_005605765.1 DUF2202 domain-containing protein -
OOL18_RS09715 2030487..2031146 - 660 WP_265410804.1 hypothetical protein -
OOL18_RS09720 2031460..2032782 - 1323 WP_005620148.1 HslU--HslV peptidase ATPase subunit -
OOL18_RS09725 2032928..2033449 - 522 WP_005599247.1 ATP-dependent protease subunit HslV -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 2007215..2044383 37168


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-124)

Antitoxin

SpoVT-AbrB domain

(6-52)


Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 15066.37 Da        Isoelectric Point: 7.3824

>T264119 WP_005609156.1 NZ_CP110664:2028569-2028967 [Actinobacillus pleuropneumoniae]
MLTYMLDTNIAIYVIKRRPIEVLDKFNLNSTRLCVSSITAAELYYGAEKSQFPERNMAVIEDFLSRLTILDYTHKAATHF
GNIKAHLSKCGKILGENDIHIAAHARSEGLVLVTNNLREFERVEGLRLDNWV

Download         Length: 399 bp

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8581.65 Da        Isoelectric Point: 4.5203

>AT264119 WP_039709385.1 NZ_CP110664:2028339-2028569 [Actinobacillus pleuropneumoniae]
MEASVFMTNRSQAVRLPAEVRFASDVKKLSVRVVGNERILAPINQSWDSFFLGSATVSDDFMTEREISTQAEREDL

Download         Length: 231 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References