Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 1805205..1805936 Replicon chromosome
Accession NZ_CP110664
Organism Actinobacillus pleuropneumoniae strain AP_123

Toxin (Protein)


Gene name tacT Uniprot ID -
Locus tag OOL18_RS08565 Protein ID WP_005598840.1
Coordinates 1805205..1805672 (-) Length 156 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID B0BRD3
Locus tag OOL18_RS08570 Protein ID WP_005619269.1
Coordinates 1805676..1805936 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OOL18_RS08540 1800565..1800936 - 372 WP_005598830.1 CrcB family protein -
OOL18_RS08545 1800939..1802003 - 1065 WP_039709309.1 MFS transporter -
OOL18_RS08550 1802098..1803207 + 1110 WP_039709310.1 anhydro-N-acetylmuramic acid kinase -
OOL18_RS08555 1803260..1804174 + 915 WP_005598836.1 N-acetylmuramic acid 6-phosphate etherase -
OOL18_RS08560 1804241..1805122 - 882 WP_265410754.1 50S ribosomal protein L11 methyltransferase -
OOL18_RS08565 1805205..1805672 - 468 WP_005598840.1 GNAT family N-acetyltransferase Toxin
OOL18_RS08570 1805676..1805936 - 261 WP_005619269.1 DUF1778 domain-containing protein Antitoxin
OOL18_RS08575 1806057..1807517 - 1461 WP_005598844.1 metalloprotease TldD -
OOL18_RS08580 1807647..1808906 + 1260 WP_005608887.1 tRNA lysidine(34) synthetase TilS -
OOL18_RS08585 1808933..1809223 - 291 WP_005598848.1 DUF5389 family protein -
OOL18_RS08590 1809225..1810118 - 894 WP_005608892.1 site-specific tyrosine recombinase XerD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(22-142)

Antitoxin

Vibrio phage ICP1, Orf50

(6-80)


Sequences

Toxin        


Download         Length: 156 a.a.        Molecular weight: 17206.22 Da        Isoelectric Point: 8.9312

>T264118 WP_005598840.1 NZ_CP110664:c1805672-1805205 [Actinobacillus pleuropneumoniae]
MHAPELLSEQHIVRYFQCGEVVLDQWLQRTALKNQQNNASKTFVVCDENKQVMGFYCLSAGSVSHQFVAGALRRNMPDPI
PVIILGRLAVDCSAQGKQLGVSMLKDAVLKSKTVANQIGIKALLVHALNPQAKQFYLKYGFSCSPIDEMVLMLKL

Download         Length: 468 bp

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9796.14 Da        Isoelectric Point: 4.4883

>AT264118 WP_005619269.1 NZ_CP110664:c1805936-1805676 [Actinobacillus pleuropneumoniae]
MRTAPINLRAMPDQRDLIDYAASILGKTRSDFMLETACQAAQNVILDRTVFQLNEQAFEQFNRLLEQPTADNPGLDKLLN
TKAVWE

Download         Length: 261 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A3N2I7

References