Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) toxTA/Tad-couple_hipB
Location 1597916..1598561 Replicon chromosome
Accession NZ_CP110664
Organism Actinobacillus pleuropneumoniae strain AP_123

Toxin (Protein)


Gene name toxT Uniprot ID B0BQU7
Locus tag OOL18_RS07520 Protein ID WP_005619674.1
Coordinates 1598190..1598561 (-) Length 124 a.a.

Antitoxin (Protein)


Gene name toxA Uniprot ID -
Locus tag OOL18_RS07515 Protein ID WP_005598477.1
Coordinates 1597916..1598209 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OOL18_RS07485 1593248..1593931 - 684 WP_005605188.1 arginine ABC transporter permease ArtM -
OOL18_RS07490 1593931..1594602 - 672 WP_005608588.1 arginine ABC transporter permease ArtQ -
OOL18_RS07495 1594608..1595327 - 720 WP_005619670.1 transporter substrate-binding domain-containing protein -
OOL18_RS07500 1595347..1596081 - 735 WP_005598473.1 arginine ABC transporter ATP-binding protein ArtP -
OOL18_RS07505 1596306..1596803 - 498 WP_005601953.1 YbhB/YbcL family Raf kinase inhibitor-like protein -
OOL18_RS07510 1596876..1597838 + 963 WP_005619672.1 calcium/sodium antiporter -
OOL18_RS07515 1597916..1598209 - 294 WP_005598477.1 helix-turn-helix domain-containing protein Antitoxin
OOL18_RS07520 1598190..1598561 - 372 WP_005619674.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
OOL18_RS07525 1598754..1600505 + 1752 WP_237610232.1 protein-disulfide reductase DsbD -
OOL18_RS07530 1600563..1601132 + 570 WP_005598484.1 elongation factor P hydroxylase -
OOL18_RS07535 1601176..1602030 - 855 WP_005598486.1 16S rRNA (cytidine(1402)-2'-O)-methyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(32-109)

Antitoxin

Cro/C1-type helix-turn-helix domain

(34-85)


Sequences

Toxin        


Download         Length: 124 a.a.        Molecular weight: 15066.57 Da        Isoelectric Point: 10.4054

>T264117 WP_005619674.1 NZ_CP110664:c1598561-1598190 [Actinobacillus pleuropneumoniae]
MYEIVFYRDKRGREPVKEFLLRLLKERQEGSRERLHKISHHLSILHLHGTRAGENYIKHLEDRIWQLRPVGDCLLFASII
RGKFVLLHYFAKQNYRIPKREIERAKVRLADLQERIKDEPYWF

Download         Length: 372 bp

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10935.81 Da        Isoelectric Point: 10.3120

>AT264117 WP_005598477.1 NZ_CP110664:c1598209-1597916 [Actinobacillus pleuropneumoniae]
MSPIGSSWTSFEQEIFDESEIAETQFRIRLILEIIETRQQLGISQRKLEKLSGVKQSMIARVEKGSVNPSLATVLKLLVP
LGKTLQIVPLDKNKTVR

Download         Length: 294 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A3N206

Antitoxin

Source ID Structure

References