Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/YoeB-YefM
Location 1503096..1503604 Replicon chromosome
Accession NZ_CP110664
Organism Actinobacillus pleuropneumoniae strain AP_123

Toxin (Protein)


Gene name relE Uniprot ID B0BQK9
Locus tag OOL18_RS07035 Protein ID WP_005605064.1
Coordinates 1503344..1503604 (+) Length 87 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID B0BQK8
Locus tag OOL18_RS07030 Protein ID WP_005598318.1
Coordinates 1503096..1503347 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OOL18_RS06990 1498632..1499180 - 549 WP_237593742.1 type IV pilus biogenesis/stability protein PilW -
OOL18_RS06995 1499234..1500415 - 1182 WP_005608495.1 bifunctional tRNA (adenosine(37)-C2)-methyltransferase TrmG/ribosomal RNA large subunit methyltransferase RlmN -
OOL18_RS07020 1501319..1502758 + 1440 WP_005608501.1 glutamate--tRNA ligase -
OOL18_RS07030 1503096..1503347 + 252 WP_005598318.1 YoeB-YefM toxin-antitoxin system antitoxin YefM Antitoxin
OOL18_RS07035 1503344..1503604 + 261 WP_005605064.1 Txe/YoeB family addiction module toxin Toxin
OOL18_RS07040 1503763..1503930 - 168 WP_005598320.1 Trm112 family protein -
OOL18_RS07045 1503932..1504912 - 981 WP_005608502.1 tetraacyldisaccharide 4'-kinase -
OOL18_RS07050 1505006..1506265 - 1260 WP_005598324.1 ATP-dependent protease ATP-binding subunit ClpX -
OOL18_RS07055 1506265..1506855 - 591 WP_005598326.1 ATP-dependent Clp endopeptidase proteolytic subunit ClpP -
OOL18_RS07060 1506977..1507369 + 393 WP_005620423.1 SufE family protein -
OOL18_RS07075 1507740..1508501 - 762 WP_039709246.1 DNA polymerase III subunit epsilon -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-73)


Sequences

Toxin        


Download         Length: 87 a.a.        Molecular weight: 10423.99 Da        Isoelectric Point: 8.0109

>T264116 WP_005605064.1 NZ_CP110664:1503344-1503604 [Actinobacillus pleuropneumoniae]
MKLTFSSNAWEDYLYWQKTDKIILKRINSLIKDIQRQPFEGIGKLEPLKFNLSGFWSRRINEEHRLIYSVEDEAILIVAC
RYHYDQ

Download         Length: 261 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9362.66 Da        Isoelectric Point: 4.5659

>AT264116 WP_005598318.1 NZ_CP110664:1503096-1503347 [Actinobacillus pleuropneumoniae]
MQAITYTEARQNLAGTMSKVAEDFEPILITRSKGGNCVLMSYEQYCSLEETAYLMRSPTNAKRLLDSVAELRQGQGIERE
LIE

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB B0BQK9

Antitoxin

Source ID Structure
AlphaFold DB B0BQK8

References